Evidence map›Paper›PMID 38640243›Full record

ArticleScience advances2024

Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

Ayumi E Pottenger, Debashish Roy, Selvi Srinivasan, Thomas E J Chavas, Vladmir Vlaskin, Duy-Khiet Ho, Vincent C Livingston, Mahdi Maktabi, Hsiuling Lin, Jing Zhang and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Revisiting 2-Substituted-4(1Journal of medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Ayumi E PottengerDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-0383-2975
Debashish RoyDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0009-0009-9940-1907
Selvi SrinivasanDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Thomas E J ChavasDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Vladmir VlaskinDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Duy-Khiet HoDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Vincent C LivingstonDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Mahdi MaktabiDepartment of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-3083-2564
Hsiuling LinDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0009-0006-6961-2330
Jing ZhangDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Brandon PybusDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-0392-225X
Karl KudybaDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5681-321X
Alison RothDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-6917-3485
Peter SenterSeagen, Bothell, WA 98021, USA.
George TysonGeorge Tyson Consulting, Los Altos Hills, CA 94022, USA.ORCID 0009-0002-4840-5085
Hans E HuberBioTD Strategies LLC, 213 Abbey Ln., Lansdale, PA 19446, USA.ORCID 0000-0002-2224-8192
David WescheCertara, Princeton, NJ 08540, USA.ORCID 0000-0002-3383-9238
Rosemary RochfordDepartment of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA.
Paul A BurkeDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5721-0792
Patrick S StaytonDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-6939-6371
University of Washington · USWalter Reed Army Institute of Research · USUniversity of Colorado Anschutz Medical Campus · USABS Consulting (United States) · USCertara (United States) · USHealth Strat (Kenya) · KESeagen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 3.3 billion people live with the threat of

Indexed as

AntimalarialsMalariaMalaria, VivaxAminoquinolinesHumansLiverAminoquinolinesAntimalarialstafenoquine

Identifiers

PMID38640243
PMCPMC11029812
OpenAlexW4394950986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.