Evidence map›Paper›PMID 38640091›Full record

GuidelineDevelopmental medicine and child neurology2024

Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update.

Darcy Fehlings, Brenda Agnew, Hortensia Gimeno, Adrienne Harvey, Kate Himmelmann, Jean-Pierre Lin, Jonathan W Mink, Elegast Monbaliu, James Rice, Emma Bohn and 1 more

Open access · hybridAbstract readPractice Guideline
In one paragraph

Guideline in Developmental medicine and child neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Standard work tools for managing pediatric baclofen pump infections and withdrawal.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  5. Neuropharmacology in pediatric traumatic brain injury.Journal of pediatric rehabilitation medicine · 2026
    Review
  6. Article
  7. Using expert-cited features to detect leg dystonia in cerebral palsy.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Dystonia: pathophysiology and the role of acupuncture in treatment.Wiener medizinische Wochenschrift (1946) · 2025
    Review
  10. Article
  11. Evidence for dystonia reduction in cerebral palsy remains limited.Developmental medicine and child neurology · 2024
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 6 countries.

Darcy FehlingsDepartment of Paediatrics, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-2680-1028
Brenda AgnewFamily Advisor AACPDM, CP-NET, Burlington, Ontario, Canada.ORCID 0000-0002-9541-5908
Hortensia GimenoBarts NHS Health and Queen Mary University of London, Wolfson Institute of Population Health, Centre for Preventive Neurology, London, UK.ORCID 0000-0003-1488-6415
Adrienne HarveyNeurodisability and Rehabilitation, Murdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0002-8294-7382
Kate HimmelmannDepartment of Pediatrics, Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-3959-9554
Jean-Pierre LinFaculty of Life Sciences & Medicine, King's Health Partners, Complex Motor Disorders Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Women's and Children's Health Institute, London, UK.
Jonathan W MinkDepartment of Neurology, University of Rochester, Rochester, NY, USA.
Elegast MonbaliuNeurorehabilitation Technology, Lab KU Leuven Campus Brugge, Brugge, Belgium.
James RicePaediatric Rehabilitation Department, Women's and Children's Hospital, North Adelaide, SA, Australia.ORCID 0000-0001-5366-4642
Emma BohnDepartment of Paediatrics, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-7966-0228
Yngve Falck-YtterCase Western Reserve University, Cleveland, OH, USA.
Holland Bloorview Kids Rehabilitation Hospital · CAAZ Sint-Jan · BECase Western Reserve University · USCollege of Family Physicians of Canada · CAGuy's and St Thomas' NHS Foundation Trust · GBMurdoch Children's Research Institute · AUQueen Mary University of London · GBUniversity of Gothenburg · SEUniversity of Rochester · USWomen's and Children's Hospital · AU

Funding

AACPDMOntario Brain InstituteWard Family to the Holland Bloorview Kids Rehabilitation Hospital Foundation
6 · The paper itself

Abstract

Dystonia, typically characterized by slow repetitive involuntary movements, stiff abnormal postures, and hypertonia, is common among individuals with cerebral palsy (CP). Dystonia can interfere with activities and have considerable impact on motor function, pain/comfort, and ease of caregiving. Although pharmacological and neurosurgical approaches are used clinically in individuals with CP and dystonia that is causing interference, evidence to support these options is limited. This clinical practice guideline update comprises 10 evidence-based recommendations on the use of pharmacological and neurosurgical interventions for individuals with CP and dystonia causing interference, developed by an international expert panel following the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The recommendations are intended to help inform clinicians in their use of these management options for individuals with CP and dystonia, and to guide a shared decision-making process in selecting a management approach that is aligned with the individual's and the family's values and preferences.

Indexed as

Cerebral PalsyDystoniaHumansNeurosurgical Procedures

Identifiers

PMID38640091
PMCPMC11579811
OpenAlexW4394951678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.