Evidence map›Paper›PMID 38639898›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2024

Narrative review on nanoparticles based on current evidence: therapeutic agents for diabetic foot infection.

Mohd Saleem, Azharuddin Sajid Syed Khaja, Soha Moursi, Tahani Almofeed Altamimi, Mohammed Salem Alharbi, Kauser Usman, Mohd Shahid Khan, Alwaleed Alaskar, Mohammad Jahoor Alam

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mohd SaleemDepartment of Pathology, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia. m.saleem@uoh.edu.sa.
Azharuddin Sajid Syed KhajaDepartment of Pathology, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.
Soha MoursiDepartment of Pathology, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.
Tahani Almofeed AltamimiDepartment of Family Medicine, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.
Mohammed Salem AlharbiDepartment of Internal Medicine, College of Medicine, University of Hail, 55211, Hail, Saudi Arabia.
Kauser UsmanDepartment of Internal Medicine, King George's Medical University, Lucknow, India.
Mohd Shahid KhanDepartment of Microbiology, Integral Institute of Medical Sciences and Research, Lucknow, India.
Alwaleed AlaskarDepartment of Diabetes and Endocrinology, King Salman Specialist Hospital, 55211, Hail, Saudi Arabia.
Mohammad Jahoor AlamDepartment of Biology, College of Science, University of Hail, 55211, Hail, Saudi Arabia.
University of Ha'il · SAIntegral University · INKing George's Medical University · IN

Funding

University of Hail RG-23162
6 · The paper itself

Abstract

Diabetes's effects on wound healing present a major treatment challenge and increase the risk of amputation. When traditional therapies fail, new approaches must be investigated. With their submicron size and improved cellular internalisation, nanoparticles present a viable way to improve diabetic wound healing. They are attractive options because of their innate antibacterial qualities, biocompatibility, and biodegradability. Nanoparticles loaded with organic or inorganic compounds, or embedded in biomimetic matrices such as hydrogels, chitosan, and hyaluronic acid, exhibit excellent anti-inflammatory, antibacterial, and antioxidant properties. Drug delivery systems (DDSs)-more precisely, nanodrug delivery systems (NDDSs)-use the advantages of nanotechnology to get around some of the drawbacks of traditional DDSs. Recent developments show how expertly designed nanocarriers can carry a variety of chemicals, transforming the treatment of diabetic wounds. Biomaterials that deliver customised medications to the wound microenvironment demonstrate potential. Delivery techniques for nanomedicines become more potent than ever, overcoming conventional constraints. Therapeutics for diabetes-induced non-healing wounds are entering a revolutionary era thanks to precisely calibrated nanocarriers that effectively distribute chemicals. This review highlights the therapeutic potential of nanoparticles and outlines the multifunctional nanoparticles of the future that will be used for complete wound healing in diabetics. The investigation of novel nanodrug delivery systems has the potential to revolutionise diabetic wound therapy and provide hope for more efficient and focused therapeutic approaches.

Indexed as

Diabetic FootNanoparticlesWound HealingAnimalsAnti-Bacterial AgentsDrug CarriersDrug Delivery SystemsHumansAnti-Bacterial AgentsDrug CarriersBiocompatibilityDiabetic woundsDrug delivery systemsNanodrug delivery systemsNanoparticles

Identifiers

PMID38639898
OpenAlexW4394956646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.