Evidence map›Paper›PMID 38639742›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.

Emanuele Pizzo, Daniel O Cervantes, Harshada Ketkar, Valentina Ripa, Drew M Nassal, Benjamin Buck, Sreema P Parambath, Valeria Di Stefano, Kanwardeep Singh, Carl I Thompson and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Aging-Induced QT Prolongation as a Potential Contributor to Longevity.Journal of cardiovascular development and disease · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Emanuele PizzoDepartment of Physiology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0002-0336-688X
Daniel O CervantesDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Harshada KetkarDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, United States.
Valentina RipaDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Drew M NassalThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Benjamin BuckDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.
Sreema P ParambathDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, United States.
Valeria Di StefanoDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Kanwardeep SinghDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Carl I ThompsonDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Peter J MohlerThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Thomas J HundThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Jason T JacobsonDepartment of Physiology, New York Medical College, Valhalla, New York, United States.
Sudhir JainDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0002-6087-8507
Marcello RotaDepartment of Physiology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0003-0187-436X
New York Medical College · USThe Ohio State University Wexner Medical Center · USThe Ohio State University · USWestchester Medical Center · US

Funding

Myocyte Repolarization and Cardiac Dysfunction with AgeR01AG055407 · NIA · NEW YORK MEDICAL COLLEGE · PI ROTA, MARCELLO · 2018 to 2022
$2.0M
Hypertension and inflammation: novel insights from human angiotensin type 1 receptor variantsR01HL146628 · NHLBI · NEW YORK MEDICAL COLLEGE · PI JAIN, SUDHIR · 2019 to 2022
$1.6M
Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophyR00HL157684 · NHLBI · OHIO STATE UNIVERSITY · PI Drew Nassal · 2024 to 2026
$747k
American Heart Association (AHA) 19TPA34850067HHS | National Institutes of Health (NIH) R01AG055407HHS | National Institutes of Health (NIH) R01HL146628NHLBI NIH HHS R00 HL157684NHLBI NIH HHS R01 HL146628NIA NIH HHS R01 AG055407
6 · The paper itself

Abstract

Diastolic dysfunction and delayed ventricular repolarization are typically observed in the elderly, but whether these defects are intimately associated with the progressive manifestation of the aging myopathy remains to be determined. In this regard, aging in experimental animals is coupled with increased late Na

Indexed as

AgingMice, Inbred C57BLMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelAction PotentialsAge FactorsAnimalsCalcium SignalingCardiomyopathiesFemaleMaleMiceMutationMyocardial ContractionPhosphorylationSerineNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSerineagingcell mechanicsdiastolic dysfunctionlate Na currentmyocytes

Identifiers

PMID38639742
PMCPMC11932541
OpenAlexW4394953208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.