Evidence map›Paper›PMID 38639585›Full record

ReviewRadiology. Imaging cancer2024

Advances in Tumor Management: Harnessing the Potential of Histotripsy.

Yash Verma, Arosh S Perera Molligoda Arachchige

Open access · diamondAbstract readReview
In one paragraph

Review in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yash Verma *From the Norfolk and Norwich University Hospital, Colney Ln, Norwich NR4 7UY, England (Y.V.); and Faculty of Medicine, Humanitas University, Via Rita Levi Montalcini, 4, 20072 Milan, Italy (A.S.P.M.A.).
Arosh S Perera Molligoda Arachchige *From the Norfolk and Norwich University Hospital, Colney Ln, Norwich NR4 7UY, England (Y.V.); and Faculty of Medicine, Humanitas University, Via Rita Levi Montalcini, 4, 20072 Milan, Italy (A.S.P.M.A.).ORCID 0000-0002-3875-0267
Norfolk and Norwich University Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue ablation techniques have long been used in clinical settings to treat various oncologic diseases. However, many of these techniques are invasive and can cause substantial adverse effects. Histotripsy is a noninvasive, nonionizing, nonthermal tissue ablation technique that has the potential to replace surgical interventions in various clinical settings. Histotripsy works by delivering high-intensity focused ultrasound waves to target tissue. These waves create cavitation bubbles within tissues that rapidly expand and collapse, thereby mechanically fractionating the tissue into acellular debris that is subsequently absorbed by the body's immune system. Preclinical and clinical studies have demonstrated the efficacy of histotripsy in treating a range of diseases, including liver, pancreatic, renal, and prostate tumors. Safety outcomes of histotripsy have been generally favorable, with minimal adverse effects reported. However, further studies are needed to optimize the technique and understand its long-term effects. This review aims to discuss the importance of histotripsy as a noninvasive tissue ablation technique, the preclinical and clinical literature on histotripsy and its safety, and the potential applications of histotripsy in clinical practice.

Indexed as

Ablation TechniquesProstatic NeoplasmsHumansKidneyLiverMaleTumor MicroenvironmentUltrasonographyAbdomen/GIAblation TechniquesClinical TrialsFocused UltrasoundGenital/ReproductiveHistotripsyNonthermal Tissue AblationPreclinical ApplicationsTumor MicroenvironmentUltrasound–High-Intensity Focused (HIFU)

Identifiers

PMID38639585
PMCPMC11148838
OpenAlexW4394954404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.