Evidence map›Paper›PMID 38639489›Full record

ArticleJournal of clinical microbiology2024

Multi-center evaluation of the Research Use Only NeuMoDx monkeypox virus (MPXV) fully automated real-time PCR assay.

Heba H Mostafa, Gavin Wall, Szu-Chi Su, Gerta Hysa, Lijie Gong, Urbain Charly Dadjeu, Helen Cheung, Andrew Pekosz, Delphine De Smet, Nikola Sklenovská and 6 more

Open access · hybridAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Diagnostic accuracy of polymerase chain reaction for detection of mpox in humans.Revista panamericana de salud publica = Pan American journal of public health · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Heba H MostafaDivision of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0274-8966
Gavin WallQIAGEN GmbH, Hilden, Germany.
Szu-Chi SuNeuMoDx Molecular Inc, a QIAGEN company, Ann Arbor, Michigan, USA.
Gerta HysaNeuMoDx Molecular Inc, a QIAGEN company, Ann Arbor, Michigan, USA.
Lijie GongNeuMoDx Molecular Inc, a QIAGEN company, Ann Arbor, Michigan, USA.
Urbain Charly DadjeuDivision of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Helen CheungDivision of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-3248-1761
Delphine De SmetUniversitair Ziekenhuis Gent, Gent, Belgium.
Nikola SklenovskáLaboratory of Clinical and Epidemiological, Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Lies LaenenDepartment of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Laura ViñuelaHospital Universitario Clínico San Cecilio, Granada, Spain.
Adolfo de SalazarHospital Universitario Clínico San Cecilio, Granada, Spain.
Ana FuentesHospital Universitario Clínico San Cecilio, Granada, Spain.
Elizaveta PadalkoUniversitair Ziekenhuis Gent, Gent, Belgium.ORCID 0000-0002-8101-6957
Federico GarciaHospital Universitario Clínico San Cecilio, Granada, Spain.ORCID 0000-0001-7611-781X
Instituto de Investigación Biosanitaria de Granada · ESJohns Hopkins University · USGhent University Hospital · BEKU Leuven · BEQiagen (Germany) · DERega Institute for Medical Research · BE

Funding

QIAGEN (QIAGEN LLC - USA)
6 · The paper itself

Abstract

The mpox outbreak, caused by monkeypox virus (MPXV), accelerated the development of molecular diagnostics. In this study, we detail the evaluation of the Research Use Only (RUO) NeuMoDx MPXV assay by multiple European and US sites. The assay was designed and developed by Qiagen for the NeuMoDx Molecular Systems. Primers and probes were tested for specificity and inclusivity IMPORTANCE: In this manuscript, we provide detailed

Indexed as

Molecular Diagnostic TechniquesMonkeypox virusMpox, MonkeypoxReal-Time Polymerase Chain ReactionSensitivity and SpecificityAutomation, LaboratoryBelgiumDNA PrimersEuropeHumansUnited StatesDNA Primersmonkeypox virus (MPXV)mpoxNeuMoDxreal-time PCR

Identifiers

PMID38639489
PMCPMC11077944
OpenAlexW4394942448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.