Evidence map›Paper›PMID 38639350›Full record

ArticleJournal of the American Heart Association2024

In Vivo Mapping of Myocardial Injury Outside the Infarct Zone: Tissue at an Intermediate Pathological State.

Kaixi Ren, Songwang Hou, Steven E Johnson, Jon Lomasney, Chad R Haney, Jungwha Lee, Zhi-Dong Ge, Daniel C Lee, Jeffrey J Goldberger, Rishi Arora and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kaixi RenFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0003-2998-4974
Songwang HouFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0009-0007-3562-5341
Steven E JohnsonFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.
Jon LomasneyDepartment of Pathology, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-0438-2427
Chad R HaneyCenter for Advanced Molecular Imaging, Chemistry of Life Processes Northwestern University Evanston IL USA.ORCID 0000-0001-5981-2925
Jungwha LeePreventive Medicine, Feinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-0806-0847
Zhi-Dong GeCardiovascular-Thoracic Surgery and the Heart Center Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0002-7045-0846
Daniel C LeeFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0001-9447-4175
Jeffrey J GoldbergerFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0001-9802-1851
Rishi AroraFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0002-0725-4332
Ming ZhaoFeinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University Chicago IL USA.ORCID 0000-0001-7956-2409
Northwestern University · US

Funding

Resource CoreP30AR072579 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Leena Sharma · 2017 to 2026
$8.3M
Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1M
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heartR01HL152712 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI, ZHAO, MING · 2021 to 2024
$3.0M
Imaging Vascular PhosphatidylethanolamineR01HL102085 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHAO, MING · 2010 to 2014
$1.9M
NCATS NIH HHS KL2 TR001424NHLBI NIH HHS R01 HL102085NHLBI NIH HHS R01 HL152712NHLBI NIH HHS R35 HL161249NIAMS NIH HHS P30 AR072579
6 · The paper itself

Abstract

backgroundThe goal was to determine the feasibility of mapping the injured-but-not-infarcted myocardium using METHODS AND

resultsCoronary occlusion was conducted in Sprague Dawley rats with preconditioning and 30-minute ligation. In vivo single-photon emission computed tomography was acquired after 3 hours (n=6) using

conclusionsThe injured-but-not-infarcted tissue, being an intermediate zone between normal and infarct, is mapped in vivo using phosphatidylethanolamine-based imaging. The intermediate zone contributes significantly to cardiac dysfunction.

Indexed as

Disease Models, AnimalMyocardial InfarctionPeptidesRadiopharmaceuticalsRats, Sprague-DawleyTomography, Emission-Computed, Single-PhotonAnimalsBacteriocinsEndothelial CellsFeasibility StudiesGene Expression ProfilingMaleMyocardiumMyocytes, CardiacOrganotechnetium CompoundsRatsBacteriocinsduramycinOrganotechnetium CompoundsPeptidesRadiopharmaceuticalstechnetium 99m HYNIC-duramycin99mTc‐duramycinacute coronary syndromeapoptosisintermediate zonemyocardial ischemia/reperfusion

Identifiers

PMID38639350
PMCPMC11179872
OpenAlexW4394954523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.