ArticleCirculation. Cardiovascular quality and outcomes2024
Association Between Life's Essential 8 Cardiovascular Health Metrics With Cardiovascular Events in the Cardiovascular Disease Lifetime Risk Pooling Project.
Article in Circulation. Cardiovascular quality and outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- A systematic review and meta-analysis of the association between cardiovascular health determined by life's essential 8 and risk of mortality and major non-communicable diseases.Frontiers in cardiovascular medicine · 2025Pooled it
- Guideline
- Behavior change intervention targeting physical activity and diet improves stress and sleep.PloS one · 2026Trial
- Effect of Daily Avocado Intake on Cardiovascular Health Assessed by Life's Essential 8: An Ancillary Study of HAT, a Randomized Controlled Trial.Journal of the American Heart Association · 2025Trial
- Life's essential 8 and incident major adverse cardiovascular events in Korea: A nationwide cohort study.American journal of preventive cardiology · 2026Article
- Cardiovascular health and depression among postpartum women in the United States.American journal of preventive cardiology · 2026Article
- Neighborhood disadvantage and cardiovascular health in early adolescents in the United States.American journal of preventive cardiology · 2026Article
- Chronic Stress and Cardiovascular Health: The MESA and MASALA Studies.American journal of preventive medicine · 2026Article
- Cardiovascular health among young adults: Do childhood neighborhoods matter?SSM - population health · 2026Article
- Association Between Cardiovascular-Kidney-Metabolic Health and Early Arterial Injury in Young Adults in the United States: The Future of Families-Cardiovascular Health Among Young Adults Study.Circulation. Population health and outcomes · 2026Article
- Dietary Inflammation, Gut Mycobiota, and Microbial Cross-Kingdom Associations with Cardiovascular Health in Older Adults.Metabolites · 2026Article
- Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.Vascular medicine (London, England) · 2026Article
- Favorable Cardiovascular Health Among Hispanic and Non-Hispanic Adults in the United States: Results From the Hispanic Community Health Study/Study of Latinos and National Health and Nutrition Examination Survey, 2008 to 2024.Journal of the American Heart Association · 2026Article
- Evaluating the incremental value of an expanded cardiovascular health score for the prevalence of abdominal aortic calcification among middle-aged and elderly individuals.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Model Analysis of the American Heart Association's Life's Essential 8: Can Physical Activity Mitigate Cardiovascular Risk Among Low-Income Individuals?Journal of the American Heart Association · 2026Article
- Evaluating the Attenuation of Black-White Disparities in Cardiovascular Disease Incidence and Total Mortality by Life's Essential 8.Circulation. Population health and outcomes · 2026Article
- Relating Cumulative Life's Essential 8 Score With Cardiovascular Disease and Death: The Framingham Heart Study.JACC. Advances · 2026Article
- Life's essential 8 in relation to incident cardiovascular disease and mortality: the prospective study of Isfahan cohort study (2001-2013).Archives of public health = Archives belges de sante publique · 2026Article
- Trends in cardiovascular health based on Life's Essential 8 among Korean adults, 2007-2023.American journal of preventive cardiology · 2026Article
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe American Heart Association recently launched updated cardiovascular health metrics, termed Life's Essential 8 (LE8). Compared with Life's Simple 7 (LS7), the new approach added sleep health as an eighth metric and updated the remaining 7 health factors and behaviors. The association of the updated LE8 score with long-term cardiovascular disease (CVD) outcomes and death is unknown.
methodsWe pooled individual-level data from 6 contemporary US-based cohorts from the Cardiovascular Lifetime Risk Pooling Project. Total LE8 score (0-100 points), LE8 score without sleep (0-100 points), and prior LS7 scores (0-14 points) were calculated separately. We used multivariable-adjusted Cox models to evaluate the association of LE8 with CVD, CVD subtypes, and all-cause mortality among younger, middle, and older adult participants. Net reclassification improvement analysis was used to measure the improvement in CVD risk classification with the addition of LS7 and LE8 recategorization based on score quartile rankings.
resultsOur sample consisted of 32 896 US adults (7836 [23.8%] Black; 14 941 [45.4%] men) followed for 642 000 person-years, of whom 9391 developed CVD events. Each 10-point higher overall LE8 score was associated with lower risk by 22% to 40% for CVD, 24% to 43% for congenital heart disease, 17% to 34% for stroke, 23% to 38% for heart failure, and 17% to 21% for all causes of mortality events across age strata. LE8 score provided more granular differentiation of the related CVD risk than LS7. Overall, 19.5% and 15.5% of the study participants were recategorized upward and downward based on LE8 versus LS7 categories, respectively, and the recategorization was significantly associated with CVD risk in addition to LS7 score. The addition of recategorization between LE8 and LS7 categories improved CVD risk reclassification across age groups (clinical net reclassification improvement, 0.06-0.12;
conclusionsThese findings support the improved utility of the LE8 algorithm for assessing overall cardiovascular health and future CVD risk.
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