Evidence map›Paper›PMID 38638530›Full record

ArticleFrontiers in cell and developmental biology2024

The NFATc1/P2X7 receptor relationship in human intervertebral disc cells.

Maria Pina Notarangelo, Letizia Penolazzi, Elisabetta Lambertini, Simonetta Falzoni, Pasquale De Bonis, Cristina Capanni, Francesco Di Virgilio, Roberta Piva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Pina NotarangeloDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Letizia PenolazziDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Elisabetta LambertiniDepartment of Chemical, Pharmaceutical and Agricultural Sciences of the University of Ferrara, Ferrara, Italy.
Simonetta FalzoniDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Pasquale De BonisNeurosurgery Department, Sant'Anna University Hospital, Ferrara, Italy.
Cristina CapanniCNR Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", Unit of Bologna, Bologna, Italy.
Francesco Di VirgilioDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Roberta PivaDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive understanding of the molecules that play key roles in the physiological and pathological homeostasis of the human intervertebral disc (IVD) remains challenging, as does the development of new therapeutic treatments. We recently found a positive correlation between IVD degeneration (IDD) and P2X7 receptor (P2X7R) expression increases both in the cytoplasm and in the nucleus. Using immunocytochemistry, reverse transcription PCR (RT-PCR), overexpression, and chromatin immunoprecipitation, we found that NFATc1 and hypoxia-inducible factor-1α (HIF-1α) are critical regulators of P2X7R. Both transcription factors are recruited at the promoter of the

Indexed as

hypoxia-inducible factor-1αintervertebral disc cellsintervertebral disc degenerationlamin A/CNFATc1 transcription factorP2X7 purinergic receptorproximity ligation assay

Identifiers

PMID38638530
PMCPMC11024252

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.