Evidence map›Paper›PMID 38638130›Full record

ArticleOral oncology reports2023

Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study.

Vivian Salama, Sara Youssef, Tianlin Xu, Kareem A Wahid, Jaime Chen, Jillian Rigert, Anna Lee, Katherine A Hutcheson, Brandon Gunn, Jack Phan and 16 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 1 institution in 1 country.

Vivian SalamaDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Sara YoussefDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Tianlin XuDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Kareem A WahidDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Jaime ChenDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Jillian RigertDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Anna LeeDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Katherine A HutchesonDepartment of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Brandon GunnDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Jack PhanDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Adam S GardenDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Steven J FrankDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
William MorrisonDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Jay P ReddyDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Michael T SpiottoDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Mohamed A NaserDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Cem DedeDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Renjie HeDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Abdallah S R MohamedDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Lisanne V van DijkDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Ruitao LinDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Carlos J RoldanDepartment of Pain Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
David I RosenthalDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Clifton D FullerDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Amy C MorenoDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
MD Anderson Head and Neck Cancer Symptom Working Group
The University of Texas MD Anderson Cancer Center · US

Funding

Paul Calabresi Clinical Oncology AwardK12CA088084 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI David S. Hong, Scott Kopetz · 2000 to 2026
$14.0M
Project 3: Inhibiting Oxidative Phosphorylation in Pancreatic CancerP50CA221707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOPETZ, SCOTT · 2019 to 2023
$11.0M
Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
Image Guided Cancer Therapy Training ProgramT32CA261856 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kristy Brock, Clifton David Fuller · 2022 to 2026
$1.2M
Provider and Patient-generated Remote Oro-Dental Health Electronic Data Capture for Algorithmic Longitudinal Evaluation and Risk-Assessment (PROHEALER)K01DE030524 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MORENO, AMY CATHERINE · 2022 to 2024
$479k
Radiation-specific Automated Dental Dose Distributions via Machine-learning based Mapping for Accurate Predictions of (Peri)odontal Problems (RADMAP)R21DE031082 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MORENO, AMY CATHERINE · 2021 to 2022
$452k
NCI NIH HHS K12 CA088084NCI NIH HHS P50 CA221707NCI NIH HHS T32 CA261856NIDCR NIH HHS K01 DE030524NIDCR NIH HHS R01 DE028290NIDCR NIH HHS R21 DE031082
6 · The paper itself

Abstract

Objectives: Pain during Radiation Therapy (RT) for oral cavity/oropharyngeal cancer (OC/OPC) is a clinical challenge due to its multifactorial etiology and variable management. The objective of this study was to define complex pain profiles through temporal characterization of pain descriptors, physiologic state, and RT-induced toxicities for pain trajectories understanding. Materials and methods: Using an electronic health record registry, 351 OC/OPC patients treated with RT from 2013 to 2021 were included. Weekly numeric scale pain scores, pain descriptors, vital signs, physician-reported toxicities, and analgesics were analyzed using linear mixed effect models and Spearman's correlation. Area under the pain curve (AUC Results: Median pain scores increased from 0 during the weekly visit (WSV)-1 to 5 during WSV-7. By WSV-7, 60% and 74% of patients reported mouth and throat pain, respectively, with a median pain score of 5. Soreness and burning pain peaked during WSV-6/7 (51%). Median AUC Conclusion: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.

Indexed as

Acute painDermatitisHead and neck cancerOral Cavity and oropharyngeal cancerOral mucositisRadiation Therapy

Identifiers

PMID38638130
PMCPMC11025722
OpenAlexW4386101366

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.