Evidence map›Paper›PMID 38637762›Full record

ArticleJournal of neurodevelopmental disorders2024

Neurobehavioral outcomes of neonatal asymptomatic congenital cytomegalovirus infection at 12-months.

Sally M Stoyell, Jed T Elison, Emily Graupmann, Neely C Miller, Jessica Emerick, Elizabeth Ramey, Kristen Sandness, Mark R Schleiss, Erin A Osterholm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sally M StoyellInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA. stoye003@umn.edu.ORCID 0009-0000-0397-8504
Jed T ElisonInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Emily GraupmannDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Neely C MillerMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Jessica EmerickMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Elizabeth RameyDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Kristen SandnessMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Mark R Schleiss *Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Erin A Osterholm *Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. oste0123@umn.edu.
University of Minnesota · US

Funding

UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Infant Brain and Behavioral Signatures of Later Emerging Risk for PsychopathologyR01MH104324 · NIMH · UNIVERSITY OF MINNESOTA · PI ELISON, JED THOMAS · 2014 to 2018
$2.6M
ACL HHS U19DD001218NCBDD CDC HHS U19 DD001218NIMH NIH HHS R01 MH104324NIMH NIH HHS U01 MH10274/ U01 MH110274NIMH NIH HHS U01 MH110274
6 · The paper itself

Abstract

backgroundCongenital cytomegalovirus (cCMV) is the most common congenital viral infection in the United States. Symptomatic infections can cause severe hearing loss and neurological disability, although ~ 90% of cCMV infections are asymptomatic at birth. Despite its prevalence, the long-term neurobehavioral risks of asymptomatic cCMV infections are not fully understood. The objective of this work was to evaluate for potential long-term neurobehavioral sequelae in infants with asymptomatic cCMV.

methodsInfants with cCMV were identified from a universal newborn cCMV screening study in a metropolitan area in the midwestern United States. Asymptomatic infants with cCMV were enrolled in a longitudinal neurodevelopmental study (N = 29). Age- and sex-matched healthy control infants (N = 193) were identified from the Baby Connectome Project (BCP), a longitudinal study of brain and behavioral development. The BCP sample supplemented an additional group of healthy control infants (N = 30), recruited from the same participant registry as the BCP specifically for comparison with infants with asymptomatic cCMV. Neurobehavioral assessments and parent questionnaires, including the Mullen Scales of Early Learning, the Repetitive Behavior Scales for Early Childhood (RBS-EC), and the Infant Toddler Social Emotional Assessment (ITSEA) were administered at 12 months of age. Neurobehavioral scores were compared between infants with asymptomatic cCMV and all identified healthy control infants.

resultsInfants with asymptomatic cCMV performed equivalently compared to healthy control infants on the neurobehavioral measures tested at 12 months of age.

conclusionsThese results indicate that at 12 months of age, infants with asymptomatic cCMV are not statistically different from controls in a number of neurobehavioral domains. Although follow-up is ongoing, these observations provide reassurance about neurobehavioral outcomes for infants with asymptomatic cCMV and inform the ongoing discussion around universal screening. Additional follow-up will be necessary to understand the longer-term outcomes of these children.

Indexed as

CytomegalovirusCytomegalovirus InfectionsBrainChild, PreschoolHumansInfantInfant, NewbornLongitudinal StudiesNeonatal ScreeningCongenital CMV infectionIntellectual disabilityTORCH infections

Identifiers

PMID38637762
PMCPMC11025208
OpenAlexW4394931695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.