ArticleBMC geriatrics2024
Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Association of sarcopenic obesity with cognitive dysfunction and dementia: a systematic review and meta-analysis.Aging clinical and experimental research · 2025Pooled it
- Improving cognition through lifestyle-induced remission of type 2 diabetes: findings from DIABEPIC-2.Acta diabetologica · 2026Article
- Association of Physical Activity with Dementia Risk in Cancer Survivors: A Korean Nationwide Cohort Study.Cancer research and treatment · 2026Article
- Body Muscle-to-Fat Ratio (BMFR) as a Promising Anthropometric Index for Use in the Evaluation of Insulin Resistance and Metabolic Disease Risk: a Narrative Review.Current obesity reports · 2025Review
- Association of Components of Severe Sarcopenia With Cognitive Decline in Older Adults: A Cross-Sectional Study.Cureus · 2025Article
- Clinical Significance of Skeletal Fat-to-Muscle Ratio in Idiopathic Hyperaldosteronism.Clinical endocrinology · 2025Article
- Association Between the Waist-Triglyceride Index and Incident Type 2 Diabetes in the Elderly: A Retrospective Cohort Study.Journal of diabetes research · 2025Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFat to muscle mass ratio (FMR), a novel index integrating fat and muscle composition, has garnered attention in age-related conditions such as type 2 diabetes mellitus (T2DM) and neurodegenerative diseases. Despite this research on the relationship between FMR and cognitive impairment (CI) in T2DM remains scarce. This study aimed to investigate the sex-specific association between FMR and CI in elderly T2DM patients.
methodsA total of 768 elderly (> 60 years) T2DM in-patients (356 men and 412 women) were recruited from the Department of Endocrinology at Tianjin Nankai University affiliated hospital. Bioelectrical Impedance Analysis (BIA) was used to assess body composition, and Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive performance. T2DM patients were categorized into normal cognitive function (NC) and cognitive impairment (CI) groups based on MoCA scores and stratified by sex. Binary logistic regression was employed to examine the association between FMR and CI.
resultsAmong the participants, 42.7% of men and 56.3% of women experienced cognitive deterioration. Women with CI exhibited lower body mass index (BMI) and skeletal muscle mass index (SMI), while men with cognitive disorders showed lower SMI, FMR, and higher fat mass index (FMI). FMR was consistently unrelated to cognition in females, irrespective of adjustment made. However, in males, FMR was significantly associated with an increasing risk of cognitive dysfunction after adjusting for demographic and clinical variables (OR: 1.175, 95% CI: 1.045-1.320, p = 0.007). Furthermore, for each 0.1 increase in FMR, the incidence of CI rose by 31.1% after additional adjustment for BMI. In males, the prevalence of CI increased sequentially across FMR quartiles (p < 0.05).
conclusionElderly T2DM men with high FMR had unfavorable cognitive function. FMR is independently associated with an increased risk of CI in male T2DM patients regardless of BMI.
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