Evidence map›Paper›PMID 38637671›Full record

ArticleScientific reports2024

Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer's disease classification.

Sait Alp, Taymaz Akan, Md Shenuarin Bhuiyan, Elizabeth A Disbrow, Steven A Conrad, John A Vanchiere, Christopher G Kevil, Mohammad A N Bhuiyan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sait AlpDepartment of Computer Engineering, Erzurum Technical University, Erzurum, Turkey.
Taymaz AkanDivision of Clinical Informatics, Department of Medicine, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
Md Shenuarin BhuiyanDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
Elizabeth A DisbrowCenter for Brain Health, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
Steven A ConradDivision of Clinical Informatics, Department of Medicine, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
John A VanchiereDepartment of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
Christopher G KevilDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.
Mohammad A N BhuiyanDivision of Clinical Informatics, Department of Medicine, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA. Nobel.Bhuiyan@lsuhs.edu.
Louisiana State University Health Sciences Center Shreveport · USErzurum Technical University · TR

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
Sigmar1 in lipid metabolismR01HL145753 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BHUIYAN, MD. SHENUARIN · 2019 to 2023
$2.6M
CSE regulation of vascular remodelingR01HL149264 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL145753NHLBI NIH HHS R01 HL149264NIA NIH HHS U01 AG024904NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

Alzheimer's disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In this study, we investigated the use of Vision Transformer (ViT) for Magnetic Resonance Image processing in the context of AD diagnosis. ViT was utilized to extract features from MRIs, map them to a feature sequence, perform sequence modeling to maintain interdependencies, and classify features using a time series transformer. The proposed model was evaluated using ADNI T1-weighted MRIs for binary and multiclass classification. Two data collections, Complete 1Yr 1.5T and Complete 3Yr 3T, from the ADNI database were used for training and testing. A random split approach was used, allocating 60% for training and 20% for testing and validation, resulting in sample sizes of (211, 70, 70) and (1378, 458, 458), respectively. The performance of our proposed model was compared to various deep learning models, including CNN with BiL-STM and ViT with Bi-LSTM. The suggested technique diagnoses AD with high accuracy (99.048% for binary and 99.014% for multiclass classification), precision, recall, and F-score. Our proposed method offers researchers an approach to more efficient early clinical diagnosis and interventions.

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesAgedBrainHumansMagnetic Resonance ImagingNeuroimagingAlzheimer’s diseaseMRISequence classificationTransfer learningVision transformer

Identifiers

PMID38637671
PMCPMC11026447
OpenAlexW4394933653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.