Evidence map›Paper›PMID 38637646›Full record

ArticleCommunications biology2024

Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida.

Allison Murawski, Thomas Fabrizio, Robert Ossiboff, Christina Kackos, Trushar Jeevan, Jeremy C Jones, Ahmed Kandeil, David Walker, Jasmine C M Turner, Christopher Patton and 12 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Allison MurawskiDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.
Thomas FabrizioDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-8960-0728
Robert OssiboffDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.ORCID 0000-0001-6951-6070
Christina KackosDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-5329-4175
Trushar JeevanDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Jeremy C JonesDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-9980-2112
Ahmed KandeilDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0003-3253-6961
David WalkerDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Jasmine C M TurnerDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-1185-6758
Christopher PattonDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-3685-4337
Elena A GovorkovaDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0001-9067-5682
Helena HauckDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.
Suzanna MickeyDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.ORCID 0000-0003-3521-4749
Brittany BarbeauDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.ORCID 0009-0009-4052-3707
Y Reddy BommineniBronson Animal Disease Diagnostic Laboratory, 2700 N John Young Parkway, Kissimmee, FL, 34745-8006, USA.
Mia TorchettiNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, IA, 50011, USA.
Kristina LantzNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, IA, 50011, USA.ORCID 0000-0002-1720-1832
Lisa KercherDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0001-6300-0452
Andrew B AllisonDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.
Peter VogelComparative Pathology Core, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID 0000-0002-7535-0545
Michael WalshDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608, USA.
Richard J WebbyDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. richard.webby@stjude.org.ORCID 0000-0002-4397-7132
St. Jude Children's Research Hospital · USUniversity of Florida · USAnimal and Plant Health Inspection Service · US

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
NIAID NIH HHS 75N93021C00016
6 · The paper itself

Abstract

Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin (Tursiops truncatus) from Florida, United States. Pathological findings include neuronal necrosis and inflammation of the brain and meninges, and quantitative real time RT-PCR reveal the brain carried the highest viral load. Virus isolated from the brain contains a S246N neuraminidase substitution which leads to reduced inhibition by neuraminidase inhibitor oseltamivir. The increased prevalence of A(H5N1) viruses in atypical avian hosts and its cross-species transmission into mammalian species highlights the public health importance of continued disease surveillance and biosecurity protocols.

Indexed as

Bottle-Nosed DolphinInfluenza A virusInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsAnimalsBirdsFloridaNeuraminidaseNeuraminidase

Identifiers

PMID38637646
PMCPMC11026403
OpenAlexW4394919321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.