Evidence map›Paper›PMID 38637476›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.

Krystina Dunston, Mark I Hunter, Eric Johannesen, Jin-Seok Jung, Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong

Open access · greenAbstract read
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Krystina DunstonDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, 1030 Hitt Street, Columbia, MO, 65211, USA.ORCID 0009-0009-9592-2203
Mark I HunterDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, 1030 Hitt Street, Columbia, MO, 65211, USA.ORCID 0000-0002-8616-5003
Eric JohannesenDepartment of Pathology Medical Science Building (MSB), University of Missouri, Columbia, MO, USA.
Jin-Seok JungDepartment of Biomedical Laboratory Science, Yonsei University Mirae Campus, 1 Yonseidae-gil, Wonju, Gangwon-do, 26493, Republic of Korea.ORCID 0009-0006-4281-4872
Tae Hoon KimDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, 1030 Hitt Street, Columbia, MO, 65211, USA.ORCID 0000-0001-7823-5457
Jung-Yoon YooDepartment of Biomedical Laboratory Science, Yonsei University Mirae Campus, 1 Yonseidae-gil, Wonju, Gangwon-do, 26493, Republic of Korea. jy_yoo@yonsei.ac.kr.ORCID 0000-0001-9366-3863
Jae-Wook JeongDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, 1030 Hitt Street, Columbia, MO, 65211, USA. jeongjw@missouri.edu.ORCID 0000-0002-5368-6478
University of Missouri Health System · USYonsei University · KRUniversity of Missouri · US

Funding

The role of cholesterol biosynthesis in metastatic and recurrent endometrialcancerR01CA264944 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Jae-Wook Jeong · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA264944NCI NIH HHS R01CA264944
6 · The paper itself

Abstract

Endometrial cancer is the most common gynecologic malignancy. PTEN is a negative regulator of PI3K signaling and is deficient in > 50% of primary human endometrial cancer. Amplification of ERBB2 promotes tumorigenesis and pathogenesis of several human cancers. However, the effect of ERBB2 targeting has not been studied in endometrial cancer with PTEN mutations. The murine model Pgr

Indexed as

CarcinogenesisEndometrial NeoplasmsErb-b2 Receptor Tyrosine KinasesMutationPTEN PhosphohydrolaseAnimalsCell ProliferationDisease Models, AnimalFemaleMiceErbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesPTEN PhosphohydrolasePten protein, mouseEndometrial CancerErbB2Preclinical animal modelPTEN

Identifiers

PMID38637476
PMCPMC12418515
OpenAlexW4394912079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.