Evidence map›Paper›PMID 38637447›Full record

ArticleEuropean journal of pediatrics2024

Impact of macronutrients intake on glycemic homeostasis of preterm infants: evidence from continuous glucose monitoring.

Silvia Guiducci, Giulia Res, Luca Bonadies, Federica Savio, Sabrina Brigadoi, Elena Priante, Daniele Trevisanuto, Eugenio Baraldi, Alfonso Galderisi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Silvia GuiducciDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Giulia ResDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Luca BonadiesDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Federica SavioDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Sabrina BrigadoiDepartment of Developmental and Social Psychology, University of Padua, Padua, Veneto, Italy.
Elena PrianteDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Daniele TrevisanutoDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Eugenio BaraldiDepartment of Woman and Child's Health, University of Padua, Padua, Italy.
Alfonso GalderisiDepartment of Woman and Child's Health, University of Padua, Padua, Italy. alfonso.galderisi@unipd.it.
University of Padua · ITYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Ministero della Salute GR-RF 2019-12368539NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Nutritional intake could influence the blood glucose profile during early life of preterm infants. We investigated the impact of macronutrient intake on glycemic homeostasis using continuous glucose monitoring (CGM). We analyzed macronutrient intake in infants born ≤ 32 weeks gestational age (GA) and/or with birth weight ≤ 1500 g. CGM was started within 48 h of birth and maintained for 5 days. Mild and severe hypoglycemia were defined as sensor glucose (SG) < 72 mg/dL and <47 mg/dL, respectively, while mild and severe hyperglycemia were SG > 144 mg/dL and >180 mg/dL. Data from 30 participants were included (age 29.9 weeks (29.1; 31.2), birthweight 1230.5 g (1040.0; 1458.6)). A reduced time in mild hypoglycemia was associated to higher amino acids intake (p = 0.011) while increased exposure to hyperglycemia was observed in the presence of higher lipids intake (p = 0.031). The birthweight was the strongest predictor of neonatal glucose profile with an inverse relationship between the time spent in hyperglycemia and birthweight (p = 0.007).  Conclusions: Macronutrient intakes influence neonatal glucose profile as described by continuous glucose monitoring. CGM might contribute to adjust nutritional intakes in preterm infants. What is Known: • Parenteral nutrition may affect glucose profile during the first days of life of preterm infants. What is New: • Continuous glucose monitoring describes the relationship between daily parenteral nutrient intakes and time spent in hypo and hyperglycemic ranges.

Indexed as

Blood GlucoseHomeostasisHypoglycemiaInfant, PrematureContinuous Glucose MonitoringFemaleGestational AgeHumansHyperglycemiaInfant, NewbornMaleMonitoring, PhysiologicNutrientsBlood GlucoseNutrientsContinuous glucose monitoringNeonatal glucoseNeonatal hyperglycemiaNeonatal hypoglycemiaNeonatal nutritionPreterm infants

Identifiers

PMID38637447
PMCPMC11192807
OpenAlexW4394933517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.