Evidence map›Paper›PMID 38637412›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Effectiveness of combined approach to recurrent respiratory papillomatosis (RRP).

Alfred Aga, Eliesa Bekteshi, Guardmond Ajasllari, Armida Kosta, Emirjona Vajushi, Rinard Kortoci, Marta Filauro, Taulant Muka, Giorgio Peretti

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alfred AgaUnit of Otorhinolaryngology-Head and Neck Surgery, American Hospital, Rruga Lord Bajroni, Tirana, Albania. frediaga@gmail.com.ORCID http://orcid.org/0000-0003-2924-233X
Eliesa BekteshiUnit of Otorhinolaryngology-Head and Neck Surgery, American Hospital, Rruga Lord Bajroni, Tirana, Albania.
Guardmond AjasllariUnit of Otorhinolaryngology-Head and Neck Surgery, American Hospital, Rruga Lord Bajroni, Tirana, Albania.
Armida KostaUnit of Otorhinolaryngology-Head and Neck Surgery, American Hospital, Rruga Lord Bajroni, Tirana, Albania.
Emirjona VajushiUnit of Otorhinolaryngology-Head and Neck Surgery, American Hospital, Rruga Lord Bajroni, Tirana, Albania.
Rinard KortociUnit of Anaesthesiology, American Hospital, Tirana, Albania.
Marta FilauroUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Taulant MukaEpistudia, 3008, Bern, Switzerland.
Giorgio PerettiUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Ospedale Policlinico San Martino · ITAlbanian University · AL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent approaches for recurrent respiratory papillomatosis including local injection of bevacizumab and HPV vaccination show promise in reducing the need for frequent surgeries. In this study we propose a new combined approach of surgery, intralesional injection of 25 mg bevacizumab and HPV vaccine that can lead to resolution of RRP. MATERIAL AND

methodsOur study involved 5 patients treated with a combination of transoral microsurgery, intralesional injection of 25 mg bevacizumab, and HPV vaccination with Gardasil 9 between April 2020 and May 2023. Standard video laryngoscopy was performed to assess the presence of papilloma and Derkay score was used to assess the severity of disease.

resultsAll 5 patients completed the study successfully and a complete response was achieved by all. The follow-up ranged from 8 to 45 months. The mean total Derkay score before treatment was 41 (range 25 to 52) and after the combined approach was 0 both anatomically and clinically in all patients.

conclusionsThis study demonstrates the effectiveness of a combined treatment approach for RRP involving surgical intervention, intralesional injection of bevacizumab, and HPV vaccination.

Indexed as

BevacizumabInjections, IntralesionalPapillomavirus InfectionsRespiratory Tract InfectionsAdolescentAdultCombined Modality TherapyFemaleHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18HumansLaryngoscopyMaleMicrosurgeryPapillomavirus VaccinesTreatment OutcomeYoung AdultBevacizumabHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18Papillomavirus VaccinesHPV vaccineIntralesional injection of BevacizumabRecurrent respiratory papillomatosisSurgery

Identifiers

PMID38637412
OpenAlexW4394912420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.