Evidence map›Paper›PMID 38637275›Full record

ArticleRenal failure2024

Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group.

Aysegul Oruc, Abdullah Sumnu, Aydın Turkmen, Taner Basturk, Egemen Cebeci, Kenan Turgutalp, Hakkı Cetinkaya, Müge Uzerk Kibar, Nurhan Seyahi, Erhan Tatar and 26 more

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Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 4 countries.

Aysegul OrucDepartment of Nephrology, Bursa Uludag University Faculty of Medicine, Bursa, Turkiye.ORCID 0000-0002-0342-9692
Abdullah SumnuDepartment of Nephrology, Medipol University Faculty of Medicine, Istanbul, Turkiye.ORCID 0000-0003-1185-9737
Aydın TurkmenDepartment of Nephrology, Istanbul University Faculty of Medicine, Istanbul, Turkiye.ORCID 0000-0003-3664-8469
Taner BasturkDepartment of Nephrology, University of Health Sciences, Etfal Hamidiye Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0003-3371-1207
Egemen CebeciDepartment of Nephrology, Istanbul Provincial Directorate of Health Istanbul Haseki Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0002-7393-5144
Kenan TurgutalpDepartment of Nephrology, Mersin University Faculty of Medicine, Training and Educational Hospital, Mersin, Turkiye.ORCID 0000-0003-0245-1844
Hakkı CetinkayaDepartment of Nephrology, University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0001-9527-3885
Müge Uzerk KibarDepartment of Nephrology, Health Ministry of Turkiye Republic Ankara Bilkent City Hospital, Ankara, Turkiye.
Nurhan SeyahiDepartment of Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkiye.ORCID 0000-0001-7427-618X
Erhan TatarDepartment of Nephrology, Izmir Provincial Directorate of Health Bozyaka Education and Research Hospital, Izmir, Turkiye.ORCID 0000-0002-5068-4231
Metin ErgulDepartment of Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye.ORCID 0000-0002-0706-6550
Ülver DericiDepartment of Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkiye.ORCID 0000-0002-9741-6779
Mehmet Deniz AylıDepartment of Nephrology, Mınıstry Of Health Dıskapı Yıldırım Beyazıt Traınıng And Research Hospıtal, Ankara, Turkiye.ORCID 0000-0003-3145-1595
Musa PınarDepartment of Nephrology, Faculty of Medicine, Sakarya University, Sakarya, Turkiye.ORCID 0000-0001-8164-6302
Betül BakarDepartment of Nephrology, Ankara Provincial Health Directorate Ankara Training and Research Hospital, Ankara, Turkiye.
Rümeyza KazancıogluDepartment of Nephrology, Faculty of Medicine, Bezmialem Vakif Univeristy, Istanbul, Turkiye.ORCID 0000-0003-1217-588X
Abdülmecit YıldızDepartment of Nephrology, Bursa Uludag University Faculty of Medicine, Bursa, Turkiye.ORCID 0000-0002-7105-8897
Ahmet Burak DirimDepartment of Nephrology, Istanbul Provincial Health Directorate ˙Istanbul Bakirköy Dr. Sadi Konuk Education And Research Hospital, Istanbul, Turkiye.ORCID 0000-0003-2262-8627
Zülfükar YılmazDepartment of Nephrology, Dicle University Faculty of Medicine, Diyarbakır, Turkiye.ORCID 0000-0002-1331-2906
Kültigin TurkmenDepartment of Nephrology, Faculty of Medicine Hospital, Necmettin Erbakan University Meram, Konya, Turkiye.ORCID 0000-0002-1667-7716
Onur TuncaDepartment of Nephrology, Faculty of Medicine, Afyonkarahisar University of Health Sciences, Afyonkarahisar, Turkiye.ORCID 0000-0003-1958-7617
Mehmet KocDepartment of Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkiye.ORCID 0000-0002-1433-8403
Sim KutlayDepartment of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkiye.ORCID 0000-0001-6385-2129
Hasan MicozkadıogluDepartment of Nephrology, Baskent University Faculty of Medicine, Dr. Turgut Noyan Adana Application and Research Hospital, Adana, Turkiye.ORCID 0000-0001-5142-5672
Alper AzakDepartment of Nephrology, Balikesir Provincial Health Directorate Atatürk City Hospital, Balıkesir, Turkiye.ORCID 0000-0001-6228-8829
Burcu BoztepeDepartment of Nephrology, Istanbul Provincial Health Directorate Haydarpasa Numune Traınıng And Research Hospıtal, Istanbul, Turkiye.
Sedat UstundagDepartment of Nephrology, Faculty of Medicine, Trakya University, Edirne, Turkiye.ORCID 0000-0002-8502-9181
Seda Şafak OzturkDepartment of Nephrology, Istanbul University Faculty of Medicine, Istanbul, Turkiye.ORCID 0000-0002-5431-7754
Abdulkadir UnsalDepartment of Nephrology, University of Health Sciences, Etfal Hamidiye Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0002-7989-4232
Serhat KaradagDepartment of Nephrology, Istanbul Provincial Directorate of Health Istanbul Haseki Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0001-9535-5063
Gülizar SahinDepartment of Nephrology, University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Istanbul, Turkiye.ORCID 0000-0002-0409-2710
Ezgi Coşgun YenigunDepartment of Nephrology, Ankara Provincial Health Directorate Ankara Training and Research Hospital, Ankara, Turkiye.ORCID 0000-0002-5963-605X
Necmi ErenDepartment of Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye.ORCID 0000-0002-2708-3470
Mustafa GulluluDepartment of Nephrology, Bursa Uludag University Faculty of Medicine, Bursa, Turkiye.ORCID 0000-0002-8911-7189
Meltem GursuDepartment of Nephrology, Faculty of Medicine, Bezmialem Vakif Univeristy, Istanbul, Turkiye.ORCID 0000-0002-9129-1127
Savaş OzturkDepartment of Nephrology, Istanbul University Faculty of Medicine, Istanbul, Turkiye.ORCID 0000-0002-0961-3810
Istanbul University · TRSağlık Bilimleri Üniversitesi · TRBursa Uludağ Üni̇versi̇tesi̇ · TRDirectorate of Health · ISBezmiâlem Vakıf Üniversitesi · TRKocaeli Üniversitesi · TRMinistry of Health · TRAnkara Bilkent City HospitalAnkara University · TRBakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi · TRBalıkesir University · TRBaşkent University · TRDicle University · TRGazi University · TRHaydarpaşa Numune Eğitim ve Araştırma Hastanesi · TRIstanbul Medipol University · TRMarmara University · TRMersin Üniversitesi · TRNecmettin Erbakan University · TRSakarya University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunoglobulin A (IgA) nephropathy (IgAN) treatment consists of maximal supportive care and, for high-risk individuals, immunosuppressive treatment (IST). There are conflicting results regarding IST. Therefore, we aimed to investigate IST results among IgAN patients in Turkiye.

methodThe data of 1656 IgAN patients in the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases Study Group were analyzed. A total of 408 primary IgAN patients treated with IST (65.4% male, mean age 38.4 ± 12.5 years, follow-up 30 (3-218) months) were included and divided into two groups according to treatment protocols (isolated corticosteroid [CS] 70.6% and combined IST 29.4%). Treatment responses, associated factors were analyzed.

resultsRemission (66.7% partial, 33.7% complete) was achieved in 74.7% of patients. Baseline systolic blood pressure, mean arterial pressure, and proteinuria levels were lower in responsives. Remission was achieved at significantly higher rates in the CS group (78%

conclusionCS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.

Indexed as

Glomerulonephritis, IGAKidney Failure, ChronicAdrenal Cortex HormonesAdultFemaleGlomerular Filtration RateHumansImmunosuppressive AgentsMaleMiddle AgedProteinuriaRetrospective StudiesTurkeyAdrenal Cortex HormonesImmunosuppressive AgentsIgA nephropathyimmunosuppressive treatmentoutcomeremissionTurkiye

Identifiers

PMID38637275
PMCPMC11028022
OpenAlexW4394960531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.