Evidence map›Paper›PMID 38636726›Full record

ArticleNeuropharmacology2024

Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress.

Kevin T Krupp, Jazmine D W Yaeger, Leighton J Ledesma, Miyuraj Harishchandra Hikkaduwa Withanage, J J Gale, Chase B Howe, Trevor J Allen, Monica Sathyanesan, Samuel S Newton, Cliff H Summers

Abstract read
In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kevin T KruppDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Jazmine D W YaegerVeterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
Leighton J LedesmaNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA.
Miyuraj Harishchandra Hikkaduwa WithanageDivision of Biostatistics and Computational Biology, The University of Iowa College of Dentistry, Iowa City, IA, USA.
J J GaleDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Chase B HoweDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA.
Trevor J AllenDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA.
Monica SathyanesanNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Samuel S NewtonNeuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Cliff H SummersDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA. Electronic address: cliff@usd.edu.

Funding

Trophic Factors in CognitionR01MH106640 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SATHYANESAN, SAMUEL NEWTON · 2016 to 2025
$3.7M
Sex Differences in the Neurobiological Significance of Orexin Stress SignalingR15MH125306 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2021 to 2021
$427k
Amygdalar Orexin Modulation of Affective DisordersR15MH104485 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2015 to 2015
$426k
national science foundationNIMH NIH HHS R01 MH106640NIMH NIH HHS R15 MH104485NIMH NIH HHS R15 MH125306
6 · The paper itself

Abstract

Psychedelic compounds have potentially rapid, long-lasting anxiolytic, antidepressive and anti-inflammatory effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT

Indexed as

Adaptation, PsychologicalAggressionAmphetaminesHallucinogensStress, PsychologicalAnimalsCoping SkillsEscape ReactionMaleMiceMice, Inbred C57BLSerotonin 5-HT2 Receptor AgonistsTumor Necrosis Factor-alpha4-iodo-2,5-dimethoxyphenylisopropylamineAmphetaminesHallucinogensSerotonin 5-HT2 Receptor AgonistsTumor Necrosis Factor-alphaAnxietyDefeatDepressionFear conditioningFreezingHypocretinLocomotionNeuroinflammationPsychedelicPTSDResilienceStress-alternatives modelSusceptibility

Identifiers

PMID38636726
PMCPMC11073902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.