ArticleImmunity2024
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Integrated Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
- ZNF200 and DDX17 regulatory loop promotes tumor growth and metastasis by activating RBPJ transcription in non-small cell lung cancer.Science China. Life sciences · 2026Article
- Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity.Nature immunology · 2026Article
- Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1.NPJ precision oncology · 2026Article
- Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers.eLife · 2026Article
- Multi-Omics reveals SPP1 + malignant and CXCR4Discover oncology · 2026Article
- LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.Cell reports. Medicine · 2026Article
- SAMHD1 drives immunosuppression in non-small cell lung cancer by promoting macrophage infiltration and restricting oncolytic adenovirus replication.Journal for immunotherapy of cancer · 2026Article
- Notch signaling in the tumor microenvironment: recent advances and targeted therapeutics.Molecular cancer · 2026Review
- Roles of Cellular Neighborhoods in Lung Cancer.Journal of Cancer · 2026Review
- Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.The breast journal · 2026Article
- Immune-tumor cell ligand-receptor axes driving metabolic reprogramming and therapeutic resistance in cancer.Frontiers in immunology · 2026Review
- From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor.Journal of pharmaceutical analysis · 2025Article
- 3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.Bioactive materials · 2025Article
- Cardiac Troponin I Promotes the Development of NSCLC Cells Through the Expression of Notch and Kras Proteins.Iranian journal of biotechnology · 2025Article
- Immunosuppressive JAG2Cancer communications (London, England) · 2025Article
- Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Research Advances in Myocardial Infarction Repair and Cardiac Regenerative Medicine via the Notch Signaling Pathway.Reviews in cardiovascular medicine · 2025Review
- Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation.Frontiers in immunology · 2025Article
- Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8International journal of biological sciences · 2025Review
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Authors and funding
28 authors at 5 institutions in 1 country.
Jay K MandulaDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Rosa A Sierra-MondragonDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Rachel V JimenezDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Darwin ChangDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Eslam MohamedCalifornia Northstate University, Elk Grove, CA 95757, USA.
Shiun ChangDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Julio A Vazquez-MartinezDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Yu CaoDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Carmen M AnadonDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27708, USA.
Sae Bom LeeDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Satyajit DasDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Léo Rocha-MungubaDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Vincent M PhamDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Roger LiDepartment of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Ahmad A TarhiniDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Muhammad FurqanHolden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.
William DaltonAster Insights, Tampa, FL 34667, USA.
Michelle ChurchmanAster Insights, Tampa, FL 34667, USA.
Carlos M Moran-SeguraAdvanced Analytical and Digital Laboratory, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Jonathan NguyenAdvanced Analytical and Digital Laboratory, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Bradford PerezDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Douglas J KojetinDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Alyssa ObermayerDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Xiaoqing YuDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Ann ChenDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Timothy I ShawDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Jose R Conejo-GarciaDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27708, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address: paulo.rodriguez@moffitt.org.
Moffitt Cancer Center · USDuke University · USCalifornia Northstate University · USUniversity of Iowa · USVanderbilt University · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MViral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0MProject 4P01CA250984 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$10.1MMolecular basis of ligand activation of the orphan NR4A nuclear receptorsR01AG070719 · NIA · VANDERBILT UNIVERSITY · PI Douglas Kojetin · 2021 to 2026
$3.7MPlant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1MFunctional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0MMitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumorsR01CA273034 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2022 to 2025
$1.9MNCI NIH HHS P01 CA250984NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA262121NCI NIH HHS R01 CA273034NIA NIH HHS R01 AG070719
Abstract
Signaling through Notch receptors intrinsically regulates tumor cell development and growth. Here, we studied the role of the Notch ligand Jagged2 on immune evasion in non-small cell lung cancer (NSCLC). Higher expression of JAG2 in NSCLC negatively correlated with survival. In NSCLC pre-clinical models, deletion of Jag2, but not Jag1, in cancer cells attenuated tumor growth and activated protective anti-tumor T cell responses. Jag2
Indexed as
Carcinoma, Non-Small-Cell LungInterferon Regulatory FactorsJagged-2 ProteinLung NeoplasmsMice, KnockoutTumor-Associated MacrophagesAnimalsCalcium-Binding ProteinsCell Line, TumorHumansJagged-1 ProteinMacrophagesMiceMice, Inbred C57BLReceptor, Notch1Receptors, NotchCalcium-Binding ProteinsInterferon Regulatory FactorsJAG2 protein, humanJag2 protein, mouseJagged-1 ProteinJagged-2 ProteinReceptor, Notch1Receptors, Notchimmunosuppression in cancerimmunosuppressive myelopoiesisJaggedmacrophage reprogrammingNotch ligandstumor-associated macrophages
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.