Evidence map›Paper›PMID 38636496›Full record

ArticleThe Journal of infectious diseases2024

Genomic Analysis and Surveillance of Respiratory Syncytial Virus Using Wastewater-Based Epidemiology.

Danielle M Allen, Marina I Reyne, Pearce Allingham, Ashley Levickas, Stephen H Bell, Jonathan Lock, Jonathon D Coey, Stephen Carson, Andrew J Lee, Cormac McSparron and 13 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Danielle M AllenSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-2212-2696
Marina I ReyneSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Pearce AllinghamSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Ashley LevickasSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Stephen H BellSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Jonathan LockSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Jonathon D CoeySchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Stephen CarsonSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Andrew J LeeSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Cormac McSparronGeography, Archaeology and Palaeoecology, School of Natural and Built Environment, Queen's University Belfast, Belfast, United Kingdom.
Behnam Firoozi NejadGeography, Archaeology and Palaeoecology, School of Natural and Built Environment, Queen's University Belfast, Belfast, United Kingdom.
James McKennaRegional Virus Laboratory (RVL), Belfast Health and Social Care Trust (BHSCT), Royal Victoria Hospital, Belfast, United Kingdom.
Mark ShannonRegional Virus Laboratory (RVL), Belfast Health and Social Care Trust (BHSCT), Royal Victoria Hospital, Belfast, United Kingdom.
Kathy LiRegional Virus Laboratory (RVL), Belfast Health and Social Care Trust (BHSCT), Royal Victoria Hospital, Belfast, United Kingdom.
Tanya CurranRegional Virus Laboratory (RVL), Belfast Health and Social Care Trust (BHSCT), Royal Victoria Hospital, Belfast, United Kingdom.
Lindsay J BroadbentSection of Virology, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Damian G DowneySchool of Medicine, Dentistry and Biomedical Sciences, Wellcome-Wolfson Institute for Experimental Medicine (WWIEM), Queen's University Belfast, Belfast, United Kingdom.
Ultan F PowerSchool of Medicine, Dentistry and Biomedical Sciences, Wellcome-Wolfson Institute for Experimental Medicine (WWIEM), Queen's University Belfast, Belfast, United Kingdom.
Helen E GrovesSchool of Medicine, Dentistry and Biomedical Sciences, Wellcome-Wolfson Institute for Experimental Medicine (WWIEM), Queen's University Belfast, Belfast, United Kingdom.
Jennifer M McKinleyGeography, Archaeology and Palaeoecology, School of Natural and Built Environment, Queen's University Belfast, Belfast, United Kingdom.
John W McGrathSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Connor G G BamfordSchool of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom.
Deirdre F GilpinSchool of Pharmacy, Queen's University Belfast, Belfast, United Kingdom.
Queen's University Belfast · GBBelfast Health and Social Care Trust · GBUniversity of Surrey · GB

Funding

Department of Health for Northern IrelandNorthern Ireland Wastewater Surveillance Programme
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) causes severe infections in infants, immunocompromised or elderly individuals resulting in annual epidemics of respiratory disease. Currently, limited clinical surveillance and the lack of predictable seasonal dynamics limit the public health response. Wastewater-based epidemiology (WBE) has recently been used globally as a key metric in determining prevalence of severe acute respiratory syndrome coronavirus 2 in the community, but its application to other respiratory viruses is limited. In this study, we present an integrated genomic WBE approach, applying reverse-transcription quantitative polymerase chain reaction and partial G-gene sequencing to track RSV levels and variants in the community. We report increasing detection of RSV in wastewater concomitant with increasing numbers of positive clinical cases. Analysis of wastewater-derived RSV sequences permitted identification of distinct circulating lineages within and between seasons. Altogether, our genomic WBE platform has the potential to complement ongoing global surveillance and aid the management of RSV by informing the timely deployment of pharmaceutical and nonpharmaceutical interventions.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsWastewaterGenome, ViralGenomicsHumansInfantPhylogenyRNA, ViralSeasonsWastewater-Based Epidemiological MonitoringRNA, ViralWastewatergenomerespiratory syncytial virusRSVsurveillancewastewater

Identifiers

PMID38636496
PMCPMC11481326
OpenAlexW4394907526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.