Evidence map›Paper›PMID 38635938›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma.

Chengcheng Yan, Melissa A Richard, Christopher J Gibson, Jianbo He, Alysia Bosworth, David K Crossman, Purnima Singh, Lindsey Hageman, Rashi Kalra, Saro H Armenian and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Lexicon for Clonal Hematopoiesis in Liquid Biopsy.Clinical and translational science · 2026
    Article
  10. Article
  11. Clones and clots in lymphoma transplant survivors.Journal of the National Cancer Institute · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Sex-Based Differences in Risk of Therapy-Related Myeloid Neoplasms.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Chengcheng YanUniversity of Alabama at Birmingham, Birmingham, AL.ORCID 0009-0006-7733-5951
Melissa A RichardBaylor College of Medicine, Houston, TX.ORCID 0000-0003-0129-9860
Christopher J GibsonDana Farber Cancer Institute, Boston, MA.ORCID 0000-0002-3700-5310
Jianbo HeUniversity of Alabama at Birmingham, Birmingham, AL.
Alysia BosworthCity of Hope, Duarte, CA.ORCID 0000-0002-0662-5699
David K CrossmanUniversity of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-0981-169X
Purnima SinghUniversity of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-4968-7398
Lindsey HagemanUniversity of Alabama at Birmingham, Birmingham, AL.
Rashi KalraUniversity of Alabama at Birmingham, Birmingham, AL.
Saro H ArmenianCity of Hope, Duarte, CA.ORCID 0000-0003-2604-8603
Julie VoseUniversity of Nebraska, Omaha, NE.ORCID 0000-0003-1015-7434
Daniel J WeisdorfUniversity of Minnesota, Minneapolis, MN.ORCID 0000-0001-8078-8579
Benjamin L EbertDana Farber Cancer Institute, Boston, MA.ORCID 0000-0003-0197-5451
Yutaka YasuiSt Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-7717-8638
Stephen J FormanCity of Hope, Duarte, CA.ORCID 0000-0002-2803-4152
Ravi BhatiaUniversity of Alabama at Birmingham, Birmingham, AL.
Smita BhatiaUniversity of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7755-5683
University of Alabama at Birmingham · USCity of Hope · USDana-Farber Cancer Institute · USBaylor College of Medicine · USSt. Jude Children's Research Hospital · USUniversity of Minnesota · USUniversity of Nebraska at Omaha · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Transplant for Lymphoma:Therapy-Related LeukemiaP50CA107399 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI KWAK, LARRY W · 2004 to 2022
$35.5M
NCI NIH HHS P30 CA013148NCI NIH HHS P50 CA107399
6 · The paper itself

Abstract

purposeTherapy-related myeloid neoplasm (t-MN) is a life-threatening complication of autologous peripheral blood stem cell transplantation (aPBSCT) for Hodgkin lymphoma (HL). Although previous studies have reported an association between clonal hematopoiesis (CH) in the infused PBSC product and subsequent post-aPBSCT risk of t-MN in patients with non-HL, information about patients with HL treated with aPBSCT is not available.

methodsWe constructed a retrospective cohort of 321 patients with HL transplanted at a median age of 34 years (range, 18-71). Targeted DNA sequencing of PBSC products performed for CH-associated or myeloid malignancy-associated genes identified pathogenic mutations in these patients.

resultsCH was identified in the PBSC product of 46 patients (14.3%) with most prominent representation of

conclusionThe presence of

Indexed as

Clonal HematopoiesisHodgkin DiseaseMutationNeoplasms, Second PrimaryTransplantation, AutologousAdolescentAdultAgedDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHumansMaleMiddle AgedDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanPPM1D protein, humanProtein Phosphatase 2CProto-Oncogene ProteinsTET2 protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID38635938
PMCPMC11585348
OpenAlexW4394908603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.