Evidence map›Paper›PMID 38635887›Full record

SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

A systematic review, meta-analysis

Joel S Burma, Marc-Antoine Roy, Courtney M Kennedy, Lawrence Labrecque, Patrice Brassard, Jonathan D Smirl

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Why historians must learn from physiologists.Experimental physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The neurovanguard concept and real-world embracement.Critical care (London, England) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joel S BurmaCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.ORCID 0000-0001-9756-5793
Marc-Antoine RoyDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Courtney M KennedyCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.
Lawrence LabrecqueDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Patrice BrassardDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.ORCID 0000-0002-6254-5044
Jonathan D SmirlCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.ORCID 0000-0003-1054-0038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous driven techniques have been utilized to assess dynamic cerebral autoregulation (dCA) in healthy and clinical populations. The current review aimed to amalgamate this literature and provide recommendations to create greater standardization for future research. The PubMed database was searched with inclusion criteria consisting of original research articles using driven dCA assessments in humans. Risk of bias were completed using Scottish Intercollegiate Guidelines Network and Methodological Index for Non-Randomized Studies. Meta-analyses were conducted for coherence, phase, and gain metrics at 0.05 and 0.10 Hz using deep-breathing, oscillatory lower body negative pressure (OLBNP), sit-to-stand maneuvers, and squat-stand maneuvers. A total of 113 studies were included, with 40 of these incorporating clinical populations. A total of 4126 participants were identified, with younger adults (18-40 years) being the most studied population. The most common techniques were squat-stands (n = 43), deep-breathing (n = 25), OLBNP (n = 20), and sit-to-stands (n = 16). Pooled coherence point estimates were: OLBNP 0.70 (95%CI:0.59-0.82), sit-to-stands 0.87 (95%CI:0.79-0.95), and squat-stands 0.98 (95%CI:0.98-0.99) at 0.05 Hz; and deep-breathing 0.90 (95%CI:0.81-0.99); OLBNP 0.67 (95%CI:0.44-0.90); and squat-stands 0.99 (95%CI:0.99-0.99) at 0.10 Hz. This review summarizes clinical findings, discusses the pros/cons of the 11 unique driven techniques included, and provides recommendations for future investigations into the unique physiological intricacies of dCA.

Indexed as

Cerebrovascular CirculationHomeostasisAdultHumansCerebral blood velocitydynamic cerebral autoregulationmean arterial pressuretranscranial Doppler ultrasoundtransfer function analysis

Identifiers

PMID38635887
PMCPMC11342731

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.