Evidence map›Paper›PMID 38635858›Full record

ReviewAmerican journal of respiratory cell and molecular biology2024

Asthma Pathogenesis: Phenotypes, Therapies, and Gaps: Summary of the Aspen Lung Conference 2023.

Sunita Sharma, Anthony N Gerber, Monica Kraft, Sally E Wenzel

Abstract readReviewConference Proceedings
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  4. Article
  5. Article
  6. Regulating Neutrophilic Asthma with IL-33: Maybe We Shouldn't Block IL-33 after All?American journal of respiratory cell and molecular biology · 2025
    Article
  7. Review
  8. Review
  9. Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025
    Review
  10. Asthma Phenotypes and Biomarkers.Respiratory care · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Serum 17Frontiers in immunology · 2025
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sunita SharmaDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Anthony N GerberDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Monica KraftDepartment of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York; and.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania.ORCID 0000-0002-4242-0164

Funding

Project 2 Impact of Innate and Adaptive Immunity At the Airway Epithelium in Severe AsthmaP01AI106684 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anuradha Ray, Sally E Wenzel · 2015 to 2026
$18.9M
Tollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI CARR, TARA F · 2016 to 2025
$14.7M
Role of Klf15 in airway smooth muscle and the response to glucocorticoidsR01HL109557 · NHLBI · NATIONAL JEWISH HEALTH · PI GERBER, ANTHONY N · 2012 to 2025
$7.2M
Aspen Lung Conference: Bridging the Gap between Innate and Adaptive Immunity in the LungR13HL164036 · NHLBI · NATIONAL JEWISH HEALTH · PI JANSSEN, WILLIAM, MAIER, LISA A · 2022 to 2022
$33k
Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and GapsR13HL168870 · NHLBI · NATIONAL JEWISH HEALTH · PI GERBER, ANTHONY N, KRAFT, MONICA · 2023 to 2023
$30k
CLC NIH HHS P01 AI106684-06A1NHLBI NIH HHS R01 HL109557NHLBI NIH HHS R13 HL164036NHLBI NIH HHS R13 HL168870NHLBI NIH HHS R13 HL168870-01NIAID NIH HHS P01 AI106684NIAID NIH HHS U19 AI125357
6 · The paper itself

Abstract

Although substantial progress has been made in our understanding of asthma pathogenesis and phenotypes over the nearly 60-year history of the Aspen Lung Conferences on asthma, many ongoing challenges exist in our understanding of the clinical and molecular heterogeneity of the disease and an individual patient's response to therapy. This report summarizes the proceedings of the 2023 Aspen Lung Conference, which was organized to review the clinical and molecular heterogeneity of asthma and to better understand the impact of genetic, environmental, cellular, and molecular influences on disease susceptibility, heterogeneity, and severity. The goals of the conference were to review new information about asthma phenotypes, cellular processes, and cellular signatures underlying disease heterogeneity and treatment response. The report concludes with ongoing gaps in our understanding of asthma pathobiology and provides some recommendations for future research to better understand the clinical and basic mechanisms underlying disease heterogeneity in asthma and to advance the development of new treatments for this growing public health problem.

Indexed as

AsthmaHumansLungPhenotypeasthmaendotypeenvironmentgeneticsphenotype

Identifiers

PMID38635858
PMCPMC11299090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.