Evidence map›Paper›PMID 38635834›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study.

Ratko Djukanović, Paul Brinkman, Johan Kolmert, Cristina Gomez, James Schofield, Joost Brandsma, Andy Shapanis, Paul J S Skipp, Anthony Postle, Craig Wheelock and 31 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Biologics in severe asthma: a state-of-the-art review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Review
  11. Review
  12. Strategies for Identifying Biomarkers in Severe Asthma.American journal of respiratory and critical care medicine · 2024
    Article
  13. Review
  14. Article
  15. Biomarkers for selecting biologic therapies in asthma.Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors at 14 institutions in 4 countries.

Ratko DjukanovićSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.ORCID 0000-0001-6039-5612
Paul BrinkmanDepartment of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, the Netherlands.
Johan KolmertInstitute of Environmental Medicine, Karolinska Institutet, and the Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
Cristina GomezInstitute of Environmental Medicine, Karolinska Institutet, and the Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
James SchofieldSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
Joost BrandsmaSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
Andy ShapanisBiological Sciences, University of Southampton, Southampton, United Kingdom.
Paul J S SkippSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
Anthony PostleSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
Craig WheelockInstitute of Environmental Medicine, Karolinska Institutet, and the Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-8113-0653
Sven-Erik DahlenInstitute of Environmental Medicine, Karolinska Institutet, and the Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
Peter J SterkDepartment of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, the Netherlands.
Thomas BrownPortsmouth Hospitals University National Health Service Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
David J JacksonGuy's Severe Asthma Centre, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom.
Adel MansurUniversity of Birmingham and Heartlands Hospital, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.ORCID 0000-0002-8615-8778
Ian PavordOxford Respiratory National Institute for Health and Care Research Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Mitesh PatelRespiratory Medicine and R&D, University Hospitals Plymouth National Health Service Trust, Plymouth, United Kingdom.
Christopher BrightlingInstitute for Lung Health and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
Salman SiddiquiInstitute for Lung Health and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
Peter BraddingInstitute for Lung Health and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
Ian SabroeClinical Research Facility, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.
Dinesh SaralayaBradford Institute for Health Research and the National Patient Recruitment Centre, Bradford, United Kingdom.
Livingstone ChishimbaClinical Sciences, Liverpool University Hospitals National Health Service Foundation Trust, Liverpool, United Kingdom.
Joanna PorterUniversity College London Respiratory and National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.ORCID 0000-0002-7307-169X
Douglas RobinsonUniversity College London Respiratory and National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Stephen FowlerDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-4524-1663
Peter H HowarthSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
Louisa LittleSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Thomas OliverSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Kayleigh HillSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Louise StantonSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Alexander AllenSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Deborah EllisSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Gareth GriffithsSouthampton Clinical Trials Unit, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Tim HarrisonNottingham Respiratory National Institute for Health and Care Research Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Ayobami AkenroyeDivision of Allergy and Clinical Immunology and.ORCID 0000-0002-1909-1470
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Liam HeaneyWellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland; and.
Rekha ChaudhuriGartnavel General Hospital and School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom.
Ramesh KurukulaaratchySchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
SoMOSA study team and the U-BIOPRED study team
NIHR Southampton Respiratory Biomedical Research Unit · GBUniversity Hospital Southampton NHS Foundation Trust · GBNational Health Service · GBKarolinska University Hospital · SENational Institute for Health Research · GBUniversity of Leicester · GBAmsterdam University Medical Centers · NLBrigham and Women's Hospital · USGartnavel General Hospital · GBKing's College London · GBQueen Alexandra Hospital · GBUniversity of Bradford · GBUniversity of Nottingham · GBUniversity of Southampton · GB

Funding

Novartis Investigator-led project
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Asthmatic AgentsAsthmaBiomarkersOmalizumabAdultAntibodies, Anti-IdiotypicBreath TestsFemaleHumansImmunoglobulin EMaleMiddle AgedSeverity of Illness IndexSputumTreatment OutcomeAnti-Asthmatic AgentsAntibodies, Anti-IdiotypicBiomarkersImmunoglobulin EOmalizumab

Identifiers

PMID38635834
PMCPMC11348961
OpenAlexW4394909238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.