Evidence map›Paper›PMID 38635321›Full record

ArticleGut microbes

The gut microbe pair of

Mingda Wang, Enkhchimeg Lkhagva, Sura Kim, Chongkai Zhai, Md Minarul Islam, Hyeon J Kim, Seong-Tshool Hong

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Respiratory diseases and the gut microbiota: an updated review.Frontiers in cellular and infection microbiology · 2025
    Review
  7. Review
  8. Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mingda WangDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0000-0001-8419-4030
Enkhchimeg LkhagvaDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0000-0002-0028-1661
Sura KimDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0000-0003-0472-5511
Chongkai ZhaiDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0009-0005-3109-9079
Md Minarul IslamDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0000-0002-4950-3210
Hyeon J KimBioLabs-LA at the Lundquist Institute for Bio Medical Innovation at Harbor UCLA, SNJ Pharma Inc, Torrance, CA, USA.ORCID 0000-0003-3117-353X
Seong-Tshool HongDepartment of Biomedical Sciences, Jeonbuk National University Medical School, Jeollabuk-Do, South Korea.ORCID 0000-0001-8254-6581
Jeonbuk National University · KRBiomed Research Institute · USShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify and validate gut microbes at the species level that provide protection against SARS-CoV-2 infection. To identify gut microbes conferring protection against COVID-19, we conducted a fecal microbiota transplantation (FMT) from an individual with no history of COVID-19 infection or immunization into a lethal COVID-19 hamster model. FMT from this COVID-19-resistant donor resulted in significant phenotypic changes related to COVID-19 sensitivity in the hamsters. Metagenomic analysis revealed distinct differences in the gut microbiome composition among the hamster groups, leading to the identification of two previously unknown bacterial species:

Indexed as

COVID-19Gastrointestinal MicrobiomeAnimalsCD8-Positive T-LymphocytesCricetinaeEubacterialesImmunity, CellularRuminococcusSARS-CoV-2betacoronavirusCD8+ T cellCOVID-19gut microbiomehost-directed vaccineSARS-CoV-2universal vaccine

Identifiers

PMID38635321
PMCPMC11028030
OpenAlexW4394913177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.