Evidence map›Paper›PMID 38635160›Full record

ArticlePsychology and aging2024

Loneliness, epigenetic age acceleration, and chronic health conditions.

Colin D Freilich, Kristian E Markon, Steve W Cole, Robert F Krueger

Abstract read
In one paragraph

Article in Psychology and aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Intersectional discrimination and noncommunicable disease risk factors among sexual minority men of color.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026
    Article
  9. Article
  10. Cumulative stress and epigenetic aging: Examining the role of psychological moderators.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  11. Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Associations Between Loneliness, Epigenetic Aging, and Multimorbidity Through Older Adulthood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Colin D FreilichDepartment of Psychology, University of Minnesota Twin Cities.ORCID 0000-0002-6183-7520
Kristian E MarkonDepartment of Psychology, University of Minnesota Twin Cities.
Steve W ColeDepartment of Psychiatry and Biobehavioral Sciences and Medicine, University of California, Los Angeles.
Robert F KruegerDepartment of Psychology, University of Minnesota Twin Cities.

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
Integrative Pathways to Cognitive, Affective, and Brain HealthU01AG077928 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson, MARGIE E LACHMAN · 2022 to 2026
$17.7M
The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twinsR01AG053217 · NIA · UNIVERSITY OF MINNESOTA · PI Robert F Krueger, Glenn I Roisman · 2016 to 2026
$9.1M
Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption StudyR01AG077742 · NIA · UNIVERSITY OF MINNESOTA · PI Robert F Krueger, Glenn I Roisman · 2022 to 2026
$3.9M
Training in genetic and neurobehavioral mechanisms of addictionT32DA050560 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Scott Ian Vrieze · 2020 to 2026
$2.0M
John D. and Catherine T. MacArthur FoundationNIA NIH HHS P01 AG020166NIA NIH HHS R01 AG053217NIA NIH HHS R01 AG077742NIA NIH HHS U01 AG077928NIA NIH HHS U19 AG051426NIDA NIH HHS T32 DA050560NIH HHS
6 · The paper itself

Abstract

Having associations with a range of adverse physical health outcomes including mortality, loneliness is increasingly recognized as a pressing public health concern, but the mechanisms studied to date do not yet explain all loneliness-related health risk. We sought to evaluate whether epigenetic influences on DNA methylation could help explain the relationship between loneliness and health. To do so, we first estimated associations between loneliness and epigenetic age acceleration (EAA) in a subsample of participants in the study of midlife in the United States (

Indexed as

DNA MethylationEpigenesis, GeneticLonelinessAdultAgedAgingChronic DiseaseFemaleHumansLongitudinal StudiesMaleMiddle AgedUnited States

Identifiers

PMID38635160
PMCPMC11283257

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.