Evidence map›Paper›PMID 38635099›Full record

ArticleClinical journal of gastroenterology2024

A case of an unreported point mutation in promoter 1B of the adenomatous polyposis coli gene, which is responsible for gastric adenocarcinoma and proximal polyposis of the stomach.

Ayaka Ishida, Yasuhiro Inokuchi, Makoto Hirata, Hiroto Narimatsu, Emi Yoshioka, Kota Washimi, Nozomu Machida, Shin Maeda

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ayaka IshidaDepartment of Palliative Medicine, National Cancer Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan. m09201009@gunma-u.ac.jp.ORCID http://orcid.org/0000-0002-0733-2839
Yasuhiro InokuchiDepartment of Gastroenterology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Makoto HirataDepartment of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan.
Hiroto NarimatsuDepartment of Genetic Medicine, Cancer Prevention and Cancer Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan.
Emi YoshiokaDepartment of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Kota WashimiDepartment of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Nozomu MachidaDepartment of Gastroenterology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Shin MaedaDepartment of Gastroenterology, Yokohama City Universal Hospital, Yokohama, Kanagawa, Japan.
Kanagawa Prefectural Hospital Organization · JPNational Cancer Center Hospital East · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 35-year-old woman of Asian descent with epigastralgia was referred to our hospital. Esophagogastroduodenoscopy revealed gastric cancer in the upper body and carpeting fundic gland polyposis in the fornix and body. Computed tomography revealed no metastases. Total colonoscopy and capsule endoscopy revealed no polyposis, except in the stomach. The patient was diagnosed with advanced gastric cancer and underwent open total gastrectomy. We speculated that her gastric cancer was a hereditary tumor due to its early onset and accompanying fundic gland polyposis. Germline multi-gene panel testing identified a single-nucleotide variant, c.-191 T > G, in exon 1B of the adenomatous polyposis coli gene, which can cause gastric adenocarcinoma and proximal polyposis of the stomach. To our knowledge, this is the first manuscript to report the variant (c.-191 T > G) in promoter 1B of the adenomatous polyposis coli gene, which is related to a predisposition to gastric adenocarcinoma and proximal polyposis of the stomach.

Indexed as

AdenocarcinomaPoint MutationStomach NeoplasmsAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAdenomatous PolypsAdultFemaleGastrectomyHumansPromoter Regions, GeneticAdenomatous Polyposis Coli ProteinAPC protein, humanAPC geneExon1BFGPsGAPPS

Identifiers

PMID38635099
OpenAlexW4394915389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.