Evidence map›Paper›PMID 38635026›Full record

ArticleEuropean journal of nutrition2024

Macronutrient composition of plant-based diets and breast cancer risk: the E3N prospective cohort study.

Nicholas A Koemel, Sanam Shah, Alistair M Senior, Gianluca Severi, Francesca R Mancini, Timothy P Gill, Stephen J Simpson, David Raubenheimer, Marie-Christine Boutron-Ruault, Nasser Laouali and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03285230 (The French E3N Prospective Cohort Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03285230 active not recruitingnot on this map

The French E3N Prospective Cohort Study (Etude Epidémiologique auprès de Femmes de la Mutuelle Générale de l'Education Nationale)

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan1990 to 2046Enrolled100,000ConditionsBreast Cancer, Colo-rectal Cancer, Parkinson Disease, Asthma
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 5 countries.

Nicholas A Koemel *Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Sanam Shah *Paris-Saclay University, UVSQ, Univ. Paris-Sud, CESP, Gustave Roussy, "Exposome and Heredity" team, Inserm, Villejuif, F-94805, France.
Alistair M SeniorCharles Perkins Centre, The University of Sydney, Sydney, Australia.
Gianluca SeveriParis-Saclay University, UVSQ, Univ. Paris-Sud, CESP, Gustave Roussy, "Exposome and Heredity" team, Inserm, Villejuif, F-94805, France.
Francesca R ManciniParis-Saclay University, UVSQ, Univ. Paris-Sud, CESP, Gustave Roussy, "Exposome and Heredity" team, Inserm, Villejuif, F-94805, France.
Timothy P GillCharles Perkins Centre, The University of Sydney, Sydney, Australia.
Stephen J SimpsonCharles Perkins Centre, The University of Sydney, Sydney, Australia.
David RaubenheimerCharles Perkins Centre, The University of Sydney, Sydney, Australia.
Marie-Christine Boutron-RuaultParis-Saclay University, UVSQ, Univ. Paris-Sud, CESP, Gustave Roussy, "Exposome and Heredity" team, Inserm, Villejuif, F-94805, France.
Nasser Laouali *Paris-Saclay University, UVSQ, Univ. Paris-Sud, CESP, Gustave Roussy, "Exposome and Heredity" team, Inserm, Villejuif, F-94805, France. nasser.laouali@um6p.ma.ORCID http://orcid.org/0000-0002-8532-456X
Michael R Skilton *Sydney Medical School, The University of Sydney, Sydney, Australia.
The University of Sydney · AUUniversité Paris-Sud · FR

Funding

Faculty of Medicine and Health, University of Sydney Executive Dean Stipend ScholarshipFondation de France Fondation de FranceInvestissement d'avenir ANR-10-COHO-0006l'Ecole Doctorale de Santé Publique, Ministère de l'enseignement supérieur, de la recherche et de l'innovation l'Ecole Doctorale de Santé Publique, Ministère de l'enseignement supérieur, de la recherche et de l'innovationLigue Contre le Cancer Ligue Contre le CancerMinistère de l'enseignement supérieur de la recherche et de l'innovation n2103586016National Health and Medical Research Council GNT1149976
6 · The paper itself

Abstract

purposeRecent evidence suggests that plant-based diets may reduce the risk of breast cancer (BC). However, the macronutrient composition of plant-based diets and its potential impact on BC risk has not been well explored. This analysis investigated the association of macronutrient composition with BC risk across a spectrum of plant-based diet indexes using a multidimensional approach.

designThis study followed 64,655 participants from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort from 1993 to 2014. Diets were evaluated using validated 208-item diet history questionnaires at baseline (1993) and follow-up (2005), to calculate adherence to the overall plant-based diet (PDI), healthful plant-based diet (hPDI), and unhealthful plant-based diet (uPDI). The association of macronutrient composition with BC risk was assessed via generalized additive time-dependent Cox models across different levels of these indexes. Response surfaces were generated to visualize compositional associations at the 25th, 50th, and 75th percentile of each index (low, moderate, and high).

resultsA total of 3,932 incident BC cases were identified during the 21-year follow-up. There was a significant association between macronutrient composition and BC risk for hPDI, uPDI, and PDI (all P < 0.001). Akaike information criterion favored the hPDI model for characterizing the association between macronutrients and BC. BC risk was highest for individuals with a lower hPDI score who also consumed a diet containing lower protein (10%), lower carbohydrate (35%), and higher fat (55%). The lowest risk of BC was observed in those with higher hPDI scores with the lowest intake of protein (10%). At higher PDI and uPDI, diets containing higher protein (30%) and fat (45%) had the highest BC risk.

conclusionThese results demonstrate a complex relationship between macronutrient composition, plant-based diet quality, and BC risk. Further research is needed to examine specific foods that may be driving these associations. REGISTRY: The protocol is registered at clinicaltrials.gov as NCT03285230.

Indexed as

Breast NeoplasmsDiet, Plant-BasedNutrientsCohort StudiesFemaleFollow-Up StudiesHumansProspective StudiesRisk FactorsSurveys and QuestionnairesNutrientsBreast cancerDietary patternsDiet compositionMacronutrientsPlant-based diet qualityPlant-based diets

Identifiers

PMID38635026
OpenAlexW4394921054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.