Evidence map›Paper›PMID 38634999›Full record

ArticleMikrochimica acta2024

Sensitive detection of HSP70 using a current-amplified biosensor based on antibody-loaded PS-AuNPs@Cys/Au modified ITO chip.

Ruming Liu, Yan Liu, Chaoyu Li, Dorothy Araba Yakoba Agyapong, Juan Feng, Lixia Tang, Hongjuan Zeng

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ruming LiuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Yan LiuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Chaoyu LiSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Dorothy Araba Yakoba AgyapongSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Juan FengSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Lixia TangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Hongjuan ZengSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China. zenghj@uestc.edu.cn.ORCID http://orcid.org/0000-0003-3969-9448
University of Electronic Science and Technology of China · CN

Funding

National Natural Science Foundation of China 31771079National Natural Science Foundation of China 61071026
6 · The paper itself

Abstract

A biosensing electrochemical platform for heat shock protein 70 (HSP70) has been developed by integrating a three-electrode indium tin oxide (ITO) on a chip. The platform includes modifications to the reference electrode and working electrode for the detection of HSP70. The new platform is constructed by assembly of HSP70 antibody on PS-AuNPs@Cys/Au indium tin oxide (ITO) electrode to create a high HSP70 sensitive surface. The PS-AuNPs@Cys/Au indium tin oxide (ITO) electrode is obtained by immersing the ITO electrode into the PS-AuNPs@Cys solution and performing constant potential deposition at -1.4 V (Ag/AgCl). The PS-AuNPs@Cys/Au film deposited on ITO glass provides a desirable substrate for the immobilization of the HSP70 antibody and improves the loading of antibody between PS-AuNPs@Cys/Au and the electrode resulting in a significant amplification. Under optimal conditions, the fabricated sensor demonstrates a linear range extending from 0.1 ng mL

Indexed as

GoldMetal NanoparticlesTin CompoundsAntibodiesHSP70 Heat-Shock ProteinsHumansAntibodiesGoldHSP70 Heat-Shock Proteinsindium tin oxideTin CompoundsElectrochemical Immunosensor; Differential pulse voltammetryHeat shock protein70 (HSP70)ITO chipPS-AuNPs@Cys/Au film

Identifiers

PMID38634999
OpenAlexW4394920339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.