Evidence map›Paper›PMID 38634914›Full record

ArticleAnnals of hematology2024

Immune reconstitution after single-unit umbilical cord blood transplantation using anti-thymoglobulin and myeloablative conditioning in adults with hematological malignancies.

Lourdes Cordón, Pedro Chorão, Beatriz Martín-Herreros, Juan Montoro, Aitana Balaguer, Manuel Guerreiro, Marta Villalba, Ana Facal, Pedro Asensi, Pilar Solves and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Lourdes Cordón *Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain. lou.cordon@gmail.com.
Pedro Chorão *Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Beatriz Martín-HerrerosHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Juan MontoroHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Aitana BalaguerHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Manuel GuerreiroHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Marta VillalbaHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Ana FacalHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Pedro AsensiHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Pilar SolvesHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Inés GómezCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, Madrid, Spain.
Marta SantiagoHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Brais LamasHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Ana BatallerHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Pablo GranadosHematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Amparo SempereHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Guillermo F SanzHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Miguel A SanzHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Jaime SanzHematology Research Group, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106, Valencia, 46026, Spain.
Hospital Universitari i Politècnic La Fe · ESInstituto de Investigación Sanitaria La Fe · ESCentro de Investigación Biomédica en Red de Cáncer · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery kinetics has been extensively studied in pediatric UCBT recipients, limited data exist for adults. We conducted a comprehensive analysis of 221 consecutive adult patients who underwent UCBT with MAC and ATG at a single institution. Our objective was to evaluate the influence of patient, disease, and transplant factors, along with acute graft-versus-host disease (aGVHD), on immune reconstitution and overall survival. Our findings confirm a delayed recovery of T cells, while B and NK cell reconstitution exhibited rapid progress, with NK cell counts reaching normal levels within 3 months post-transplantation and B cells within 6 months. Within CD3

Indexed as

Antilymphocyte SerumCord Blood Stem Cell TransplantationGraft vs Host DiseaseHematologic NeoplasmsImmune ReconstitutionTransplantation ConditioningAdolescentAdultAgedFemaleHumansKiller Cells, NaturalMaleMiddle AgedMyeloablative AgonistsYoung AdultAntilymphocyte SerumMyeloablative AgoniststhymoglobulinAdultsAntithymocyte globulinCord blood transplantImmune reconstitution

Identifiers

PMID38634914
OpenAlexW4394920369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.