Evidence map›Paper›PMID 38634759›Full record

ArticleACS chemical neuroscience2024

Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer.

Lin Qiu, Hao Jiang, Kevin Cho, Yanbo Yu, Lynne A Jones, Tianyu Huang, Joel S Perlmutter, Robert J Gropler, Matthew R Brier, Gary J Patti and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Evaluation of [AJNR. American journal of neuroradiology · 2026
    Article
  2. Review
  3. Automated production of radiotracer [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lin QiuDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.ORCID 0000-0001-8823-4132
Hao JiangDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Kevin ChoCenter for Mass Spectrometry and Metabolic Tracing, Department of Chemistry, Department of Medicine, Washington University, Saint Louis, Missouri 63130, United States.ORCID 0000-0002-3041-3506
Yanbo YuDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Lynne A JonesDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.ORCID 0000-0002-5607-4901
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Matthew R BrierDepartments of Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Gary J PattiCenter for Mass Spectrometry and Metabolic Tracing, Department of Chemistry, Department of Medicine, Washington University, Saint Louis, Missouri 63130, United States.ORCID 0000-0002-3748-6193
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Zhude TuDepartment of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.ORCID 0000-0003-0325-835X
Washington University in St. Louis · US

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
NIBIB NIH HHS P41 EB025815NIEHS NIH HHS R35 ES028365NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS134586
6 · The paper itself

Abstract

The sphingosine-1-phosphate receptor 1 (S1PR1) radiotracer [

Indexed as

BrainPositron-Emission TomographyRadiopharmaceuticalsAnimalsCarbon RadioisotopesFluorine RadioisotopesHumansMaleRatsRats, Sprague-DawleySphingosine-1-Phosphate ReceptorsCarbon RadioisotopesFluorine RadioisotopesRadiopharmaceuticalsSphingosine-1-Phosphate Receptors[11C]CS1P1[18F]FS1P1[18F]TZ82121human clinical studyN-oxideradiometaboliteradiosynthesisS1PR1

Identifiers

PMID38634759
PMCPMC11103254
OpenAlexW4394918162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.