Evidence map›Paper›PMID 38634742›Full record

ArticlePathology international2024

Predominant CD8

Kenta Tominaga, Etsuko Toda, Kazuhiro Takeuchi, Shoichiro Takakuma, Emi Sakamoto, Hideaki Kuno, Yusuke Kajimoto, Yasuhiro Terasaki, Shinobu Kunugi, Akiko Mii and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Predominant CD8Pathology international · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Kenta TominagaDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2871-426X
Etsuko TodaDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Kazuhiro TakeuchiDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Shoichiro TakakumaDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Emi SakamotoDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Hideaki KunoDivision of Nephrology and Hypertension, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Yusuke KajimotoDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Yasuhiro TerasakiDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Shinobu KunugiDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Akiko MiiDepartment of Nephrology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki-shi, Kanagawa, Japan.ORCID http://orcid.org/0000-0003-0326-8267
Yukinao SakaiDepartment of Endocrinology, Metabolism and Nephrology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Mika TerasakiDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4364-9251
Nippon Medical School · JPJikei University School of Medicine · JPNippon Medical School Hospital · JPNippon Medical School Musashi Kosugi Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) can provide survival benefits to cancer patients; however, they sometimes result in the development of renal immune-related adverse events (irAEs). Tubulointerstitial nephritis (TIN) is the most representative pathological feature of renal irAEs. However, the clinicopathological entity and underlying pathogenesis of ICI-induced TIN are unclear. Therefore, we compared the clinical and histological features of this condition with those of non-ICI drug-induced TIN. Age and C-reactive protein levels were significantly higher in ICI-induced TIN, but there were no significant differences in renal function. Immunophenotyping of ICI-induced TIN showed massive T cell and macrophage infiltration with fewer B cells, plasma cells, neutrophils, and eosinophils. Compared with those in non-ICI drug-induced TIN, CD4

Indexed as

CD8-Positive T-LymphocytesImmune Checkpoint InhibitorsNephritis, InterstitialT-Lymphocytes, RegulatoryAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedImmune Checkpoint Inhibitorsimmune checkpoint inhibitorregulatory T cellstubulointerstitial nephritis

Identifiers

PMID38634742
PMCPMC11551812
OpenAlexW4394915451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.