ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024
Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol.
2 registry-linked trialsOpen access · greenAbstract readMulticenter Study
In one paragraph
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Transducers of Physical Activity Consortium
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol
Who cites it
23 citing papers in PubMed, 16 citations in OpenAlex.
- Exerkines in precision management of metabolic diseases.Chinese medical journal · 2026Review
- Multi-omics signatures of circulating factors associated with cardiorespiratory fitness adaptations in individuals with prediabetes.Cardiovascular diabetology · 2026Article
- Review
- Aerobic Exercise Response Variation and Cardiorespiratory Fitness in Adults with Coronary Heart Disease: An SDir Meta-Analysis of Randomized Controlled Trials.Journal of cardiovascular development and disease · 2026Review
- Biomarkers as Temporal Signals: A Decision-Linked Multi-Layer Framework for Exercise Recovery, Overload, and Adaptation.International journal of molecular sciences · 2026Review
- Epigenetic and Neurogenomic Mechanisms Linking Physical Activity to Brain Plasticity and Cognitive Function.Genes · 2026Review
- Molecular Biomarkers of Training Responses: A Systems Framework for Exercise Adaptation and Athlete Monitoring.International journal of molecular sciences · 2026Review
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise.bioRxiv : the preprint server for biology · 2026Article
- Exercise modulation of the alternative splicing landscape in human tissues.bioRxiv : the preprint server for biology · 2026Article
- Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.bioRxiv : the preprint server for biology · 2026Article
- Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease.Kidney international reports · 2026Article
- PTM encoding: decoding the mechanisms of exercise-induced metabolic memory through spatiotemporal modification networks.Frontiers in sports and active living · 2026Review
- Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in "moderate-intensity exercise".Frontiers in immunology · 2026Review
- WMRE2030: integrating wearable devices, multi-omics, and artificial intelligence-driven real-time feedback into a daily-scale closed-loop framework for a new era of precision exercise.Frontiers in physiology · 2026Review
- Multidimensional Modeling to Maximize Adaptations to eXercise: the MJournal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Accelerating the translation of findings from the MoTrPAC study to benefit clinical care: a qualitative analysis.BMC primary care · 2025Article
- Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells.Physiological reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
94 authors at 20 institutions in 2 countries.
MoTrPAC Study Group
John M JakicicUniversity of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0001-6800-9368
Wendy M KohrtUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Joseph A HoumardEast Carolina University, Greenville, North Carolina, United States.ORCID 0000-0003-3682-5410
Michael E MillerWake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Shlomit Radom-AizikUniversity of California, Irvine, Irvine, California, United States.ORCID 0009-0004-4023-7026
Blake B RasmussenUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0000-0001-7854-5375
Eric RavussinPennington Biomedical Research Center, Baton Rouge, Louisiana, United States.
Monica SerraUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Cynthia L StoweWake Forest University School of Medicine, Biostatistics and Data Science, Winston-Salem, North Carolina, United States.ORCID 0000-0002-1887-3294
Scott TrappeBall State University, Muncie, Indiana, United States.ORCID 0000-0002-6438-431X
Hiba AbouassiDuke University, Durham, North Carolina, United States.
Joshua N AdkinsPacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States.
D Lee AlekelNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Euan AshleyStanford University, Stanford, California, United States.ORCID 0000-0001-9418-9577
Marcas M BammanThe University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-5017-5453
Bryan C BergmanUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-9561-1052
Daniel H BessesenUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Nicholas T BroskeyEast Carolina University, Greenville, North Carolina, United States.ORCID 0000-0002-1197-5116
Thomas W BufordThe University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-9541-4358
Charles F BurantUniversity of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-9189-5003
Haiying ChenWake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Jeffrey W ChristleStanford University, Stanford, California, United States.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.ORCID 0000-0001-8259-9245
Paul M CoenAdvent Health - Translational Research Institute, Orlando, Florida, United States.
David CollierEast Carolina University, Greenville, North Carolina, United States.
Katherine A CollinsDuke University, Durham, North Carolina, United States.
Daniel M CooperUniversity of California, Irvine, Irvine, California, United States.ORCID 0000-0003-4022-0043
Tiffany CortesUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Gary R CutterThe University of Alabama at Birmingham, School of Public Health, Birmingham, Alabama, United States.
Gabriel DubisEast Carolina University, Greenville, North Carolina, United States.
Facundo M FernándezGeorgia Institute of Technology, Atlanta, Georgia, United States.
Jonathon FirnhaberEast Carolina University, Greenville, North Carolina, United States.
Daniel E FormanUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United States.
David A GaulGeorgia Institute of Technology, Atlanta, Georgia, United States.
Nicole GayDepartment of Genetics, Stanford University, Stanford, California, United States.ORCID 0000-0001-9138-9354
Robert E GersztenBroad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.
Bret H GoodpasterAdvent Health - Translational Research Institute, Orlando, Florida, United States.
Marina A GritsenkoPacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States.
Fadia HaddadUniversity of California, Irvine, Irvine, California, United States.
Kim M HuffmanDuke University, Durham, North Carolina, United States.
Olga IlkayevaDuke University Medical Center, Durham, North Carolina, United States.
Catherine M JankowskiUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Christopher JinDepartment of Genetics, Stanford University, Stanford, California, United States.
Neil M JohannsenPennington Biomedical Research Center, Baton Rouge, Louisiana, United States.
Johanna JohnsonDuke University, Durham, North Carolina, United States.ORCID 0000-0001-9766-1814
Leslie KellyDuke University, Durham, North Carolina, United States.
Erin KershawUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United States.
William E KrausWake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0003-1930-9684
Maren LaughlinNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Bridget LesterBall State University, Muncie, Indiana, United States.
Malene E LindholmStanford University, Stanford, California, United States.
Adam LowePennington Biomedical Research Center, Baton Rouge, Louisiana, United States.
Ching-Ju LuUniversity of Florida, Gainesville, Florida, United States.
Joan McGowanNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Edward L MelansonUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-9151-9745
Stephen MontgomeryDepartment of Pathology, Stanford University, Stanford, California, United States.
Samuel G MooreGeorgia Institute of Technology, Atlanta, Georgia, United States.
Kerrie L MoreauUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-9298-047X
Michael MuehlbauerDuke University Medical Center, Durham, North Carolina, United States.
Nicolas MusiCedars Sinai Medical Center, Los Angeles, California, United States.
Venugopalan D NairIcahn School of Medicine at Mount Sinai, New York, New York, United States.
Christopher B NewgardDuke University Medical Center, Durham, North Carolina, United States.
Anne B NewmanUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Barbara NicklasWake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Bradley C NindlUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Kelly OrmondStanford University, Stanford, California, United States.
Paul D PiehowskiPacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States.
Wei-Jun QianPacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-5393-2827
Tuomo RankinenPennington Biomedical Research Center, Baton Rouge, Louisiana, United States.
W Jack RejeskiWake Forest University, Winston-Salem, North Carolina, United States.
Jeremy RobbinsBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.
Renee J RogersUniversity of Kansas Medical Center, Kansas City, Kansas, United States.
Jessica L RooneyLarner College of Medicine at the University of Vermont, Burlington, Vermont, United States.
Scott RushingWake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
James A SanfordPacific Northwest National Laboratory, Oregon Health and Science University, Portland, Oregon, United States.
Irene E SchauerUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0003-0575-7566
Robert S SchwartzUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Stuart C SealfonIcahn School of Medicine at Mount Sinai, New York, New York, United States.
Cris SlentzDuke University, Durham, North Carolina, United States.
Ruben SloanEast Carolina University, Greenville, North Carolina, United States.
Kevin S SmithDepartment of Pathology, Stanford University, Stanford, California, United States.
Michael SnyderDepartment of Genetics, Stanford University, Stanford, California, United States.ORCID 0000-0003-0784-7987
Jessica SpahnUniversity of Texas Medical Branch, Galveston, Texas, United States.
Lauren M SparksAdvent Health - Translational Research Institute, Orlando, Florida, United States.ORCID 0000-0002-8724-6016
Maja Stefanovic-RacicUniversity of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-2833-7089
Charles J TannerEast Carolina University, Greenville, North Carolina, United States.
Anna Thalacker-MercerThe University of Alabama at Birmingham, Birmingham, Alabama, United States.
Russell TracyLarner College of Medicine at the University of Vermont, Burlington, Vermont, United States.
Todd A TrappeBall State University, Muncie, Indiana, United States.ORCID 0000-0002-0609-5632
Elena VolpiUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.ORCID 0000-0001-8776-0384
Martin J WalshIcahn School of Medicine at Mount Sinai, New York, New York, United States.
Matthew T WheelerStanford University, Stanford, California, United States.ORCID 0000-0001-8721-3022
Leslie WillisDuke University, Durham, North Carolina, United States.
Duke University · USStanford University · USUniversity of Colorado Anschutz Medical Campus · USEast Carolina University · USWake Forest University · USPacific Northwest National Laboratory · USUniversity of Pittsburgh · USPennington Biomedical Research Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · USBall State University · USGeorgia Institute of Technology · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · USUniversity of California, Irvine · USUniversity of Kansas Medical Center · USBroad Institute · USTranslational Research Institute for Metabolism and Diabetes · USUniversity of Vermont · USAdventHealth Orlando · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MMoTrPAC Supplemental Funding for MillerU24AR071113 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jon Peter Durda, Karyn A Esser · 2017 to 2026
$28.8MUniversity of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8MPAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STUART C. SEALFON, Martin John Walsh · 2017 to 2026
$18.5MStanford/Salk MoTrPAC Site for Genomes, Epigenomes and TranscriptomesU24DK112348 · NIDDK · STANFORD UNIVERSITY · PI Stephen Montgomery, MICHAEL P. SNYDER · 2017 to 2026
$18.4MTranslational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3MMolecular Transducers of Physical Activity Consortium Adult Clinical CenterU01AR071130 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUSI, NICOLAS, RASMUSSEN, BLAKE B · 2017 to 2024
$17.7MProMoTr: A Proteomics Center for MoTrPACU24DK112349 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Joshua N. Adkins · 2017 to 2026
$17.5MThe Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7MA Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2MMoTrPAC DXA Quality ControlU01AR071128 · NIAMS · DUKE UNIVERSITY · PI HOUMARD, JOSEPH A, KRAUS, WILLIAM E · 2017 to 2025
$15.2Mlongitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, STEVEN A WEINMAN · 2022 to 2026
$14.9MHHS | National Institutes of Health (NIH) U01AG055133HHS | National Institutes of Health (NIH) U01AG055135HHS | National Institutes of Health (NIH) U01AG055137HHS | National Institutes of Health (NIH) U01AR071124HHS | National Institutes of Health (NIH) U01AR071128HHS | National Institutes of Health (NIH) U01AR071130HHS | National Institutes of Health (NIH) U01AR071133HHS | National Institutes of Health (NIH) U01AR071150HHS | National Institutes of Health (NIH) U01AR071158HHS | National Institutes of Health (NIH) U01AR071160HHS | National Institutes of Health (NIH) U24AR071113HHS | National Institutes of Health (NIH) U24DK112326HHS | National Institutes of Health (NIH) U24DK112331HHS | National Institutes of Health (NIH) U24DK112340HHS | National Institutes of Health (NIH) U24DK112341HHS | National Institutes of Health (NIH) U24DK112342HHS | National Institutes of Health (NIH) U24DK112348HHS | National Institutes of Health (NIH) U24DK112349HHS | National Institutes of Health (NIH) U24OD026629NIAMS NIH HHS U01 AR071124NIAMS NIH HHS U01 AR071128NIAMS NIH HHS U01 AR071130NIAMS NIH HHS U01 AR071133NIAMS NIH HHS U01 AR071150NIAMS NIH HHS U01 AR071158NIAMS NIH HHS U01 AR071160NIAMS NIH HHS U24 AR071113NIA NIH HHS P30 AG028740NIA NIH HHS U01 AG055133NIA NIH HHS U01 AG055135NIA NIH HHS U01 AG055137NIBIB NIH HHS U24 EB023674NIDDK NIH HHS P30 DK040561NIDDK NIH HHS U24 DK112326NIDDK NIH HHS U24 DK112331NIDDK NIH HHS U24 DK112340NIDDK NIH HHS U24 DK112341NIDDK NIH HHS U24 DK112342NIDDK NIH HHS U24 DK112348NIDDK NIH HHS U24 DK112349NIEHS NIH HHS P30 ES025128NIGMS NIH HHS P20 GM144269NIH HHS U24 OD026629NIH HHS U24 OD036598
Abstract
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular responses to exercise has not been developed. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a multicenter study designed to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. MoTrPAC contains both a preclinical and human component. The details of the human studies component of MoTrPAC that include the design and methods are presented here. The human studies contain both an adult and pediatric component. In the adult component, sedentary participants are randomized to 12 wk of Control, Endurance Exercise Training, or Resistance Exercise Training with outcomes measures completed before and following the 12 wk. The adult component also includes recruitment of highly active endurance-trained or resistance-trained participants who only complete measures once. A similar design is used for the pediatric component; however, only endurance exercise is examined. Phenotyping measures include weight, body composition, vital signs, cardiorespiratory fitness, muscular strength, physical activity and diet, and other questionnaires. Participants also complete an acute rest period (adults only) or exercise session (adults, pediatrics) with collection of biospecimens (blood only for pediatrics) to allow for examination of the molecular responses. The design and methods of MoTrPAC may inform other studies. Moreover, MoTrPAC will provide a repository of data that can be used broadly across the scientific community.
Indexed as
ExerciseResistance TrainingAdolescentAdultBody CompositionCardiorespiratory FitnessChildEndurance TrainingFemaleHumansMaleMuscle StrengthResearch DesignYoung Adultadipose tissuebiospecimensmolecular transducersphysical activityskeletal muscle
Identifiers
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Registered trials
NCT03960827ClinicalTrials.gov
NCT04151199ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.