Evidence map›Paper›PMID 38634469›Full record

ArticleeLife2024

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration.

Edgar M Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Edgar M PeraVertebrate Developmental Biology Laboratory, Department of Laboratory Medicine, Lund Stem Cell Center, University of Lund, Lund, Sweden.ORCID https://orcid.org/0000-0002-0625-0006
Josefine Nilsson-De MouraVertebrate Developmental Biology Laboratory, Department of Laboratory Medicine, Lund Stem Cell Center, University of Lund, Lund, Sweden.ORCID https://orcid.org/0009-0008-9408-6189
Yuriy PomeshchikiPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund Stem Cell Center, Strategic Research Area MultiPark, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-1412-7403
Laurent RoyboniPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund Stem Cell Center, Strategic Research Area MultiPark, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-5532-4964
Ivana MilasVertebrate Developmental Biology Laboratory, Department of Laboratory Medicine, Lund Stem Cell Center, University of Lund, Lund, Sweden.
Lund University · SE

Funding

Lund University MultiParkSwedish Childhood Cancer Fund ProJ11/101Swedish Research Council 2009-4951Swedish Research Council 2021-02284
6 · The paper itself

Abstract

We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of SerpinE2 ┤HtrA1 protease ┤Syndecan-4 → NC cell migration.

Indexed as

High-Temperature Requirement A Serine Peptidase 1Neural CrestSerpin E2AnimalsCell MovementFibroblast Growth FactorsSignal TransductionXenopus laevisXenopus ProteinsFibroblast Growth FactorsHigh-Temperature Requirement A Serine Peptidase 1Serpin E2Xenopus Proteinscollective cell migrationdevelopmental biologyembryoextracellular matrixneural crestproteolysisserine proteasexenopus

Identifiers

PMID38634469
PMCPMC11026092
OpenAlexW4387576143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.