Evidence map›Paper›PMID 38634358›Full record

Observational studyThe Laryngoscope2024

Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis.

Daniel M Beswick, Christine M Liu, Jonathan B Overdevest, Anna Zemke, Aastha Khatiwada, David A Gudis, Jessa E Miller, Adam Kimple, Jeremy P Tervo, Emily DiMango and 29 more

Open access · hybridAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 13 institutions in 1 country.

Daniel M BeswickDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.ORCID 0000-0001-8612-5442
Christine M LiuDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.ORCID 0000-0001-9985-4775
Jonathan B OverdevestDepartment of Otolaryngology-Head and Neck Surgery, Columbia University, New York, New York, U.S.A.ORCID 0000-0002-1152-2512
Anna ZemkeDivision of Pulmonary Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
Aastha KhatiwadaDepartment of Biostatistics, National Jewish Health, Denver, Colorado, U.S.A.
David A GudisDepartment of Otolaryngology-Head and Neck Surgery, Columbia University, New York, New York, U.S.A.ORCID 0000-0002-1938-9349
Jessa E MillerDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.ORCID 0000-0001-9769-187X
Adam KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
Jeremy P TervoDepartment of Otolaryngology-Head and Neck Surgery, Columbia University, New York, New York, U.S.A.
Emily DiMangoDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, New York, U.S.A.
Jennifer L GoralskiDepartment of Pulmonary Medicine, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
Claire KeatingDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, New York, U.S.A.
Brent SeniorDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
Amanda L StapletonDepartment of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
Patricia H EshaghianDepartment of Pulmonary Medicine, University of California, Los Angeles, California, U.S.A.
Jess C MaceDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, U.S.A.
Karolin MarkarianCTSI, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.
Jeremiah A AltDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, U.S.A.ORCID 0000-0003-0560-5028
Todd E BodnerDepartment of Psychology, Portland State University, Portland, Oregon, U.S.A.
Naweed I ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt Health, Nashville, Tennessee, U.S.A.
Anne E GetzDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, U.S.A.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, U.S.A.
Ashoke KhanwalkerDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, U.S.A.
Jivianne T LeeDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.ORCID 0000-0002-0711-855X
Douglas A LiDepartment of Pulmonary Medicine, University of California, Los Angeles, California, U.S.A.
Meghan NorrisDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, U.S.A.ORCID 0000-0003-4454-0861
Cameran OwensDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, U.S.A.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, U.S.A.ORCID 0000-0003-2072-982X
Katie PochDepartment of Medicine, National Jewish Health, Denver, Colorado, U.S.A.
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Greenville, South Carolina, U.S.A.
Kristine A SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, U.S.A.
Timothy L SmithDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, U.S.A.ORCID 0000-0002-6424-7083
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, U.S.A.ORCID 0000-0002-4304-595X
Jeffrey D SuhDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.
Grant A TurnerDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, U.S.A.
Marilene B WangDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.
Milene T SaavedraDepartment of Medicine, National Jewish Health, Denver, Colorado, U.S.A.
Jennifer L Taylor CousarDepartment of Medicine, National Jewish Health, Denver, Colorado, U.S.A.
University of California, Los Angeles · USNational Jewish Health · USUniversity of North Carolina at Chapel Hill · USColumbia University · USOregon Health & Science University · USStanford University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Utah · USPulmonary and Allergy Associates · USUniversity of Pittsburgh · USMedical University of South Carolina · USPortland State University · USVanderbilt Health · US

Funding

Neurocognitive & neuropsychiatric impact of chemosensory alterations: Implications of olfactory dysfunction in COVID-19K23DC019678 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OVERDEVEST, JONATHAN B · 2021 to 2025
$893k
Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
Cystic Fibrosis Foundation BESWIC20A0Cystic Fibrosis Foundation BESWIC22Y5Cystic Fibrosis Foundation TAYLOR19A0Cystic Fibrosis Foundation ZEMKE19A0Marshall and Margherite McComb FoundationNIDCD NIH HHS K23 DC019678NIDCD NIH HHS R25 DC020151NIDCD NIH HHS R25DC020151
6 · The paper itself

Abstract

objectivesThe 22-question SinoNasal Outcome Test (SNOT-22) assesses chronic rhinosinusitis (CRS) severity. We aimed to identify predictors of SNOT-22 score improvement following highly effective modulator therapy (HEMT) initiation and to corroborate the SNOT-22 minimal clinically important difference (MCID) in adults with cystic fibrosis (CF).

methodsProspective observational data was pooled from four studies across 10 US centers investigating people with CF (PwCF) and CRS. Three studies evaluated HEMT's impact on CRS. For participants enrolled prior to HEMT initiation, SNOT-22 scores were obtained at baseline and after 3-6 months of HEMT. Multivariate regression identified predictors of improvement. Cronbach's alpha and four distribution-based methods were used to assess internal consistency and calculate the MCID of the SNOT-22.

resultsA total of 184 PwCF participated with mean baseline SNOT-22 scores ranging from 18.1 to 56.7. Cronbach's alpha was ≥0.90 across sites. Participants at sites with pre- and post-HEMT data reported improvement in SNOT-22 scores after initiating HEMT (all p < 0.05). Worse baseline SNOT-22 score (odds ratio (OR): 1.05, p < 0.001, 95% CI: 1.02-1.08), F508del homozygosity (OR: 4.30, p = 0.040, 95% CI: 1.14-18.99), and absence of prior modulator therapy (OR: 4.99, p = 0.017, 95% CI: 1.39-20.11) were associated with greater SNOT-22 improvement. The mean MCID calculated via distribution-based methods was 8.5.

conclusionWorse baseline sinonasal symptoms, F508del homozygosity, and absence of prior modulator therapy predicted greater improvement after HEMT initiation. The mean MCID for SNOT-22 in PwCF is 8.5 points, similar to non-CF individuals with CRS, and provides a threshold specifically for PwCF. The SNOT-22 has strong internal consistency in PwCF. LEVEL OF EVIDENCE: 3 Laryngoscope, 134:3965-3973, 2024.

Indexed as

Cystic FibrosisRhinitisSinusitisAdultAminophenolsChronic DiseaseCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansMaleMiddle AgedMinimal Clinically Important DifferenceProspective StudiesQuinolonesSeverity of Illness IndexSino-Nasal Outcome TestAminophenolsCystic Fibrosis Transmembrane Conductance RegulatorivacaftorQuinolonesCFTR modulator therapychronic rhinosinusitiscystic fibrosiselexacaftor/tezacaftor/ivacaftorminimal clinically important difference

Identifiers

PMID38634358
PMCPMC11305934
OpenAlexW4394918411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.