Evidence map›Paper›PMID 38634138›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Podocyte-specific silencing of acid sphingomyelinase gene to abrogate hyperhomocysteinemia-induced NLRP3 inflammasome activation and glomerular inflammation.

Dandan Huang, Jason M Kidd, Yao Zou, Xiaoyuan Wu, Ningjun Li, Todd W B Gehr, Pin-Lan Li, Guangbi Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Differential Effects of High Methionine Diet on Biochemical Parameters in Normal and Diabetic Rat Models.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2025
    Article
  4. Article
  5. Sphingolipid signaling in kidney diseases.American journal of physiology. Renal physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dandan HuangDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Jason M KiddDivision of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Yao ZouDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.ORCID 0000-0001-5775-2957
Xiaoyuan WuDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Ningjun LiDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.ORCID 0000-0001-5371-3790
Todd W B GehrDivision of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Pin-Lan LiDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Guangbi LiDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.ORCID 0000-0003-3836-3272
Virginia Commonwealth University · US

Funding

Hypertension and glomerular injury in hyperhomocysteinemia - role of inflammatory exosomesR01DK054927 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN · 1998 to 2023
$6.7M
Lysosome dysfunction in podocytopathy and associated hypertensionR01DK120491 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN · 2018 to 2022
$2.4M
HHS | National Institutes of Health (NIH) DK054927HHS | National Institutes of Health (NIH) DK120491NIDDK NIH HHS R01 DK054927NIDDK NIH HHS R01 DK120491
6 · The paper itself

Abstract

Acid sphingomyelinase (ASM) has been reported to increase tissue ceramide and thereby mediate hyperhomocysteinemia (hHcy)-induced glomerular nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation, inflammation, and sclerosis. In the present study, we tested whether somatic podocyte-specific silencing of

Indexed as

HyperhomocysteinemiaInflammasomesMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPodocytesSphingomyelin PhosphodiesteraseAnimalsDisease Models, AnimalExtracellular VesiclesGene SilencingGlomerulonephritisKidney GlomerulusMaleMiceMice, Inbred C57BLASMase, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSphingomyelin Phosphodiesteraseacid sphingomyelinaseextracellular vesiclehyperhomocysteinemiaNLRP3 inflammasomepodocyte

Identifiers

PMID38634138
PMCPMC11380990
OpenAlexW4394920779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.