Evidence map›Paper›PMID 38634135›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Double-negative T cells have a reparative role after experimental severe ischemic acute kidney injury.

Kyungho Lee, Sepideh Gharaie, Johanna T Kurzhagen, Andrea M Newman-Rivera, Lois J Arend, Sanjeev Noel, Hamid Rabb

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Immunomodulatory Functions of Intercalated Cells in Kidney Autoimmunity.bioRxiv : the preprint server for biology · 2025
    Article
  7. Neuroprotective role of DNTαβ Cell transplantation on modulating immune microenvironment in spinal cord injured mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Kyungho LeeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-2627-0220
Sepideh GharaieDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Johanna T KurzhagenDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Andrea M Newman-RiveraDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-2032-4438
Lois J ArendDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-5434-7630
Sanjeev NoelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-9818-1177
Hamid RabbDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-4761-1103
Johns Hopkins University · US

Funding

Acute Kidney Injury and Double Negative T CellsR01DK104662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HAMAD, ABDEL RAHIM, RABB, HAMID · 2015 to 2023
$3.8M
Acute kidney injury and microbiomeR01DK123342 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RABB, HAMID · 2020 to 2024
$3.0M
TIGIT in acute kidney injury and repairR01DK132278 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Sanjeev Noel · 2023 to 2026
$1.9M
Cytek Aurora full spectrum flow cytometric analyzerS10OD026859 · OD · JOHNS HOPKINS UNIVERSITY · PI WANG, ZACK Z. · 2019 to 2019
$242k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK104662NIDDK NIH HHS R01 DK104662NIDDK NIH HHS R01 DK123342NIDDK NIH HHS R01 DK132278NIH HHS S10 OD026859
6 · The paper itself

Abstract

T cells mediate organ injury and repair. A proportion of unconventional kidney T cells called double-negative (DN) T cells (TCR

Indexed as

Acute Kidney InjuryGlomerular Filtration RateMice, Inbred C57BLReperfusion InjuryT-Lymphocytes, RegulatoryAdoptive TransferAnimalsCells, CulturedDisease Models, AnimalEpithelial CellsFibrosisKidneyKidney TubulesMaleMicePhenotypeacute kidney injuryischemia-reperfusion injurylymphocytesrepairT cells

Identifiers

PMID38634135
PMCPMC11386976
OpenAlexW4394920983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.