Evidence map›Paper›PMID 38634129›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models.

Anjana Chaudhary, Zhibin He, Daniel J Atwood, Makoto Miyazaki, Ozgur A Oto, Allen Davidoff, Charles L Edelstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Reactive Oxygen Species in Cystic Kidney Disease.Antioxidants (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anjana ChaudharyDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Zhibin HeDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-8235-300X
Daniel J AtwoodDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Makoto MiyazakiDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-8704-8511
Ozgur A OtoDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Allen DavidoffXORTX Therapeutics Inc., Calgary, Alberta, Canada.
Charles L EdelsteinDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-1330-632X
University of Colorado Anschutz Medical Campus · US

Funding

The role of MLKL in the regulation of vascular calcification in CKDR01HL132318 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2016 to 2025
$3.8M
The transcriptional control of vascular calcification in diseaseR01HL157064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Makoto Miyazaki · 2023 to 2026
$2.5M
A Novel Driver of Hyperphosphatemia and Vascular Calcification in CKDR01DK124901 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BLAINE, JUDITH T.,, MIYAZAKI, MAKOTO · 2021 to 2024
$1.9M
NHLBI NIH HHS R01 HL132318NHLBI NIH HHS R01 HL157064NIDDK NIH HHS R01 DK124901
6 · The paper itself

Abstract

Humans are predisposed to gout because they lack uricase that converts uric acid to allantoin. Rodents have uricase, resulting in low basal serum uric acid. A uricase inhibitor raises serum uric acid in rodents. There were two aims of the study in polycystic kidney disease (PKD):

Indexed as

Disease Models, AnimalKidneyPolycystic Kidney DiseasesUrate OxidaseUric AcidAnimalsCytokinesEnzyme InhibitorsFemaleInflammasomesMaleMiceMice, Inbred C57BLOxonic AcidOxypurinolRatsCytokinesEnzyme InhibitorsInflammasomesOxonic AcidOxypurinolTRPP Cation ChannelsUrate OxidaseUric AcidXanthine Oxidaseoxypurinolpolycystic kidneyuric aciduricasexanthine oxidase

Identifiers

PMID38634129
PMCPMC11918273
OpenAlexW4394921019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.