Evidence map›Paper›PMID 38634075›Full record

ArticleJBMR plus2024

Multi-scale cortical bone traits vary in females and males from two mouse models of genetic diversity.

Nicole Migotsky, Surabhi Kumar, John T Shuster, Jennifer C Coulombe, Bhavya Senwar, Adrian A Gestos, Charles R Farber, Virginia L Ferguson, Matthew J Silva

Abstract read
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nicole MigotskyOrthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110, United States.
Surabhi KumarOrthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110, United States.
John T ShusterOrthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110, United States.
Jennifer C CoulombeDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, United States.
Bhavya SenwarDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, United States.
Adrian A GestosMaterials Instrumentation and Multimodal Imaging Core, University of Colorado, Boulder, CO 80309, United States.
Charles R FarberCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States.
Virginia L FergusonDepartment of Mechanical Engineering, University of Colorado, Boulder, CO 80309, United States.
Matthew J SilvaOrthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110, United States.

Funding

Response of the Osteoporotic Skeleton to Mechanical LoadingR01AR047867 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2001 to 2026
$8.4M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
A Systems Genetics Approach to Identify BMD GenesR01AR071657 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARBER, CHARLES R, GERSTENFELD, LOUIS CHARLES · 2018 to 2022
$3.9M
Imaging, Modeling and Engineering of Diabetic TissuesT32DK108742 · NIDDK · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2016 to 2020
$1.4M
3D X-RAY PHASE CONTRAST MICROSCOPE FOR SUBMICRON QUANTITATIVE BIOLOGICAL IMAGINGS10OD021694 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2016 to 2016
$1.0M
INTERDISCIPLINARY TRAINING IN MECHANOBIOLOGY FROM NM TO CMT32EB018266 · NIBIB · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2014 to 2018
$987k
Cabinet microCT System for Musculoskeletal Specimen ImagingS10OD028573 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2020 to 2020
$407k
Influence of Genetic Background on Bone Anabolic Response to Mechanical LoadingR21AR079052 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2022 to 2023
$394k
NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR047867NIAMS NIH HHS R01 AR071657NIAMS NIH HHS R21 AR079052NIBIB NIH HHS T32 EB018266NIDDK NIH HHS T32 DK108742NIH HHS S10 OD021694NIH HHS S10 OD028573
6 · The paper itself

Abstract

Understanding the genetic basis of cortical bone traits can allow for the discovery of novel genes or biological pathways regulating bone health. Mice are the most widely used mammalian model for skeletal biology and allow for the quantification of traits that cannot easily be evaluated in humans, such as osteocyte lacunar morphology. The goal of our study was to investigate the effect of genetic diversity on multi-scale cortical bone traits of 3 long bones in skeletally-mature mice. We measured bone morphology, mechanical properties, material properties, lacunar morphology, and mineral composition of mouse bones from 2 populations of genetic diversity. Additionally, we compared how intrabone relationships varied in the 2 populations. Our first population of genetic diversity included 72 females and 72 males from the 8 inbred founder strains used to create the Diversity Outbred (DO) population. These 8 strains together span almost 90% of the genetic diversity found in mice (

Indexed as

biomechanicsbone matrixbone microCTgenetic researchosteocytes

Identifiers

PMID38634075
PMCPMC11021811

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.