Evidence map›Paper›PMID 38634023›Full record

ReviewJournal of conservative dentistry and endodontics2024

Mines of cytokine: A treasure trove in pulpal and periapical diseases.

Neelam D Chandwani, Unnati Devanand Gedam, Ranjana Deshmukh, Darshan M Dakshindas, Manish Shrigiriwar

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of conservative dentistry and endodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  9. Potential application of a combined extract ofJournal of conservative dentistry and endodontics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Neelam D ChandwaniDepartment of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Unnati Devanand GedamDepartment of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Ranjana DeshmukhDepartment of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Darshan M DakshindasDepartment of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Nagpur, Maharashtra, India.
Manish ShrigiriwarDepartment of FMT, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
All India Institute of Medical Sciences, NagpurGovernment Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulpitis is a special disease of dental pulp. It causes localized inflammation, due to various inflammatory mediators such as cytokines and chemokines. These inflammatory mediators are responsible for various reparative and resorptive processes in the dental pulp. The balance between these processes ultimately determines the viability of the tooth. Due to the important properties of various inflammatory markers, the correlation of cytokinin gene expression in various stages of inflammation becomes necessary to focus on. Several studies in the past have focused on the importance of such correlation to help in diagnostic applications. The nature of these inflammatory mediators can help us in diagnostic evaluation. Several attempts have been made to focus on these associations so that it can assist in making clinical decisions effectively. The data available are vast but are the most neglected topic. This review article briefly outlines and summarizes the importance of various inflammatory mediators such as cytokinin and chemokines in various pathways of pulpal and periapical inflammation in explanatory and diagrammatic forms. Knowledge gained about pulpal inflammatory response may aid in understanding the molecular level of inflammatory pulpal and periapical diseases, which shall modify our future diagnostic modalities. Several medicaments are used in the treatment of minimal to advanced dental caries which leads to periapical infections. Thorough understanding of these medicaments can resolve secondary infection and can improve the prognosis of the treated tooth.

Indexed as

Chemokinescytokinesinterferonsinterleukinsperiapical inflammationpulpal diseasespulpitis

Identifiers

PMID38634023
PMCPMC11019815
OpenAlexW4392558151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.