Evidence map›Paper›PMID 38633880›Full record

ArticlePNAS nexus2024

A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets.

Nicholas K H Ostan, Gregory B Cole, Flora Zhiqi Wang, Sean E Reichheld, Gaelen Moore, Chuxi Pan, Ronghua Yu, Christine Chieh-Lin Lai, Simon Sharpe, Hyun O Lee and 2 more

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nicholas K H OstanDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Gregory B ColeDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID https://orcid.org/0000-0003-3444-4374
Flora Zhiqi WangDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sean E ReichheldMolecular Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID https://orcid.org/0000-0002-6979-5695
Gaelen MooreDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Chuxi PanDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID https://orcid.org/0000-0002-0065-0535
Ronghua YuDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
Christine Chieh-Lin LaiDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID https://orcid.org/0009-0003-8035-0712
Simon SharpeDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID https://orcid.org/0000-0001-8016-3915
Hyun O LeeDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Anthony B SchryversDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
Trevor F MoraesDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID https://orcid.org/0000-0001-9883-6145
University of Toronto · CAUniversity of Calgary · CAHospital for Sick Children · CA

Funding

Using gonococcal TonB-dependent transporters as vaccine antigensU19AI144182 · NIAID · GEORGIA STATE UNIVERSITY · PI GRAY-OWEN, SCOTT D · 2019 to 2023
$9.3M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
NIAID NIH HHS U19 AI144182NIH HHS S10 OD018090
6 · The paper itself

Abstract

Mammalian hosts combat bacterial infections through the production of defensive cationic antimicrobial peptides (CAPs). These immune factors are capable of directly killing bacterial invaders; however, many pathogens have evolved resistance evasion mechanisms such as cell surface modification, CAP sequestration, degradation, or efflux. We have discovered that several pathogenic and commensal proteobacteria, including the urgent human threat

Indexed as

antimicrobial peptidesphase separationsecreted proteins

Identifiers

PMID38633880
PMCPMC11022072
OpenAlexW4393581432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.