Evidence map›Paper›PMID 38633867›Full record

ArticleMaterials today. Bio2024

Trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment for articular osteochondral defect repair.

Hongying Chen, Jinyi Huang, Xiaomeng Li, Weiwei Zhao, Yujie Hua, Zhenfeng Song, Xianwei Wang, Zhikun Guo, Guangdong Zhou, Wenjie Ren and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hongying ChenSchool of Basic Medical Sciences of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Medical and Protective Products, Xinxiang, Henan, 453003, China.
Jinyi HuangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University, Shanghai, 200011, China.
Xiaomeng LiSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Weiwei ZhaoSchool of Basic Medical Sciences of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Medical and Protective Products, Xinxiang, Henan, 453003, China.
Yujie HuaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University, Shanghai, 200011, China.
Zhenfeng SongSchool of Basic Medical Sciences of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Medical and Protective Products, Xinxiang, Henan, 453003, China.
Xianwei WangThe Key Laboratory of Medical Tissue Regeneration in Henan Province of Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Zhikun GuoThe Key Laboratory of Medical Tissue Regeneration in Henan Province of Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Guangdong ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University, Shanghai, 200011, China.
Wenjie RenSchool of Basic Medical Sciences of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Medical and Protective Products, Xinxiang, Henan, 453003, China.
Yongkun SunSchool of Basic Medical Sciences of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Medical and Protective Products, Xinxiang, Henan, 453003, China.
Xinxiang Medical University · CNShanghai Jiao Tong University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Commonly, articular osteochondral tissue exists significant differences in physiological architecture, mechanical function, and biological microenvironment. However, the development of biomimetic scaffolds incorporating upper cartilage, middle tidemark-like, and lower subchondral bone layers for precise articular osteochondral repair remains elusive. This study proposed here a novel strategy to construct the trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment of both mechanical and biological factors. The cartilage-specific microenvironment was achieved through the grafting of kartogenin (KGN) into gelatin

Indexed as

HydrogelsMicroenvironmentOsteochondral repairTrilayered scaffolds

Identifiers

PMID38633867
PMCPMC11021956
OpenAlexW4394681142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.