ArticleInfectious diseases & clinical microbiology2022
Serological Evidence of Scrub Typhus in Mizoram, North Eastern Region of India.
Article in Infectious diseases & clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- The diagnostic accuracy of point-of-care nucleic acid-based isothermal amplification assays for scrub typhus: a systematic review and meta-analysis.Frontiers in microbiology · 2024Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Differentiating scrub typhus from other acute febrile illnesses is difficult due to non-specificity of clinical symptoms and relative absence of eschar in Indian population. Antibody based serological tests are mainstay of scrub typhus diagnosis. To order to determine the performance of immunochromatography and IgM ELISA, immunochromatography and scrub typhus IgM ELISA were performed to detect the presence of antibodies against Materials and Methods: A cross-sectional study was carried out in the Department of Microbiology, Civil Hospital Aizawl and Department of Microbiology, Civil Hospital Lunglei, Mizoram over a period of one year from October 1, 2018 to September 31, 2019. Serum samples from patients with acute febrile illness were processed for the detection of scrub typhus. A total of 253 samples were subjected to immunochromatography and IgM ELISA. Results: Using scrub typhus IgM ELISA as gold standard, the sensitivity, specificity and negative predictive value were calculated. Of the 253 serum samples tested, 36 were positive by both scrub typhus rapid test and IgM ELISA. 27 samples which were negative by scrub typhus rapid test reacted positive by IgM ELISA. 66 samples which were positive by scrub typhus rapid test were negative by IgM ELISA. Conclusion: Owing to the limitations of scrub typhus rapid test and immunfluorescence assay (IFA), commercially available recombinant IgM ELISA which has a good sensitivity and specificity may be an alternative in laboratories with moderate set up.
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Registered trials
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