ArticleBiological psychiatry global open science2024
Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood.
Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.Behavior genetics · 2026Article
- Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.Research square · 2026Article
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Attention-deficit/hyperactivity disorder (ADHD) in adults: evidence base, uncertainties and controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.Translational psychiatry · 2024Article
- Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis.Molecular autism · 2024Article
- Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis.medRxiv : the preprint server for health sciences · 2024Article
- Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with diagnostic criteria requiring symptoms to begin in childhood. We investigated whether individuals diagnosed as children differ from those diagnosed in adulthood with respect to shared and unique architecture at the genome-wide and gene expression level of analysis. Methods: We used genomic structural equation modeling (SEM) to investigate differences in genetic correlations ( Results: Compared with the childhood subgroup, adulthood-diagnosed ADHD exhibited a significantly larger negative Conclusions: This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increased misdiagnosis for those diagnosed later in life. Top transcriptome-wide SEM results implicated genes related to neuronal function and clinical characteristics (e.g., sleep).
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