Evidence map›Paper›PMID 38633099›Full record

ArticleBiomedical optics express2024

All-optical dual module platform for motility-based functional scrutiny of microencapsulated probiotic bacteria.

Zhe Wang, Giusy Giugliano, Jaromir Behal, Michela Schiavo, Pasquale Memmolo, Lisa Miccio, Simonetta Grilli, Filomena Nazzaro, Pietro Ferraro, Vittorio Bianco

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhe WangInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.
Giusy GiuglianoInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.
Jaromir BehalInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.ORCID https://orcid.org/0000-0001-5537-4091
Michela SchiavoInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.
Pasquale MemmoloInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.ORCID https://orcid.org/0000-0002-9607-7728
Lisa MiccioInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.
Simonetta GrilliInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.
Filomena NazzaroIstituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma, 64, Avellino 83100, Italy.
Pietro FerraroInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.ORCID https://orcid.org/0000-0002-0158-3856
Vittorio BiancoInstitute of Applied Sciences and Intelligent Systems "E. Caianiello", National Research Council (ISASI-CNR), Via Campi Flegrei, 34, Pozzuoli, 80078, Italy.ORCID https://orcid.org/0000-0003-1956-4976
Institute of Applied Science and Intelligent Systems · ITInstitute of Food Science · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotic bacteria are widely used in pharmaceutics to offer health benefits. Microencapsulation is used to deliver probiotics into the human body. Capsules in the stomach have to keep bacteria constrained until release occurs in the intestine. Once outside, bacteria must maintain enough motility to reach the intestine walls. Here, we develop a platform based on two label-free optical modules for rapidly screening and ranking probiotic candidates in the laboratory. Bio-speckle dynamics assay tests the microencapsulation effectiveness by simulating the gastrointestinal transit. Then, a digital holographic microscope 3D-tracks their motility profiles at a single element level to rank the strains.

Identifiers

PMID38633099
PMCPMC11019698
OpenAlexW4389893860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.