Evidence map›Paper›PMID 38633084›Full record

ArticleBiomedical optics express2024

Combined ion beam irradiation platform and 3D fluorescence microscope for cellular cancer research.

Andrew D Harken, Naresh T Deoli, Citlali Perez Campos, Brian Ponnaiya, Guy Garty, Grace S Lee, Malte J Casper, Shikhar Dhingra, Wenze Li, Gary W Johnson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integration of an electron beam ion trap source into an electrostatic accelerator for pre-clinical cancer research.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrew D HarkenRadiological Research Accelerator Facility, Columbia University Irving Medical Center, 136 S. Broadway, P.O. Box 21, Irvington, New York 10533, USA.
Naresh T DeoliRadiological Research Accelerator Facility, Columbia University Irving Medical Center, 136 S. Broadway, P.O. Box 21, Irvington, New York 10533, USA.
Citlali Perez CamposLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.
Brian PonnaiyaRadiological Research Accelerator Facility, Columbia University Irving Medical Center, 136 S. Broadway, P.O. Box 21, Irvington, New York 10533, USA.
Guy GartyRadiological Research Accelerator Facility, Columbia University Irving Medical Center, 136 S. Broadway, P.O. Box 21, Irvington, New York 10533, USA.
Grace S LeeLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.
Malte J CasperLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.ORCID https://orcid.org/0000-0002-6879-691X
Shikhar DhingraLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.
Wenze LiLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.ORCID https://orcid.org/0000-0001-5256-7787
Gary W JohnsonCenter for Radiological Research, Columbia University Irving Medical Center, 630 W. 168th Street, New York, NY 10032, USA.
Sally A AmundsonCenter for Radiological Research, Columbia University Irving Medical Center, 630 W. 168th Street, New York, NY 10032, USA.
Peter W GrabhamCenter for Radiological Research, Columbia University Irving Medical Center, 630 W. 168th Street, New York, NY 10032, USA.
Elizabeth M C HillmanLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, NY, 10027, USA.ORCID https://orcid.org/0000-0001-5511-1451
David J BrennerRadiological Research Accelerator Facility, Columbia University Irving Medical Center, 136 S. Broadway, P.O. Box 21, Irvington, New York 10533, USA.

Funding

TR&D 3P41EB002033 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRENNER, DAVID JONATHAN · 2003 to 2018
$17.0M
Flexible Tools for Pre-Clinical Studies to Answer Key Questions UnderlyingHeavy-Ion RadiotherapyU01CA236554 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRENNER, DAVID JONATHAN, HILLMAN, ELIZABETH M. C. · 2019 to 2022
$2.6M
6 MeV/amu ion linac for deep-penetration microbeam and millimeter-beam charged-particle irradiations in small animals and biological tissuesS10OD025190 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRENNER, DAVID JONATHAN · 2018 to 2018
$2.0M
SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organismsU01NS094296 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HILLMAN, ELIZABETH M. C. · 2015 to 2017
$2.0M
NCI NIH HHS U01 CA236554NIBIB NIH HHS P41 EB002033NIH HHS S10 OD025190NINDS NIH HHS U01 NS094296
6 · The paper itself

Abstract

To improve particle radiotherapy, we need a better understanding of the biology of radiation effects, particularly in heavy ion radiation therapy, where global responses are observed despite energy deposition in only a subset of cells. Here, we integrated a high-speed swept confocally-aligned planar excitation (SCAPE) microscope into a focused ion beam irradiation platform to allow real-time 3D structural and functional imaging of living biological samples during and after irradiation. We demonstrate dynamic imaging of the acute effects of irradiation on 3D cultures of U87 human glioblastoma cells, revealing characteristic changes in cellular movement and intracellular calcium signaling following ionizing irradiation.

Identifiers

PMID38633084
PMCPMC11019671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.