ArticleBiomedical optics express2024
Dual modality intravascular catheter system combining pulse-sampling fluorescence lifetime imaging and polarization-sensitive optical coherence tomography.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Development of solid-state fluorescence lifetime standards for clinical applications using dyed epoxy resins.Journal of biomedical optics · 2026Article
- From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease.Light, science & applications · 2026Review
- High-speed multimodal intravascular ultrasound and photoacoustic imaging system for atherosclerosis characterization.Biomedical optics express · 2026Article
- High-speed, wide-field, fiber-based PS-OCT system with real-time surface Stokes feedback for circular input polarization.Biomedical optics express · 2026Article
- Intracoronary Optical Coherence Tomography: Technological Innovations and Clinical Implications in Cardiology.Current treatment options in cardiovascular medicine · 2025Review
- Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology.Biomedical optics express · 2024Article
- High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser.Biomedical optics express · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
The clinical management of coronary artery disease and the prevention of acute coronary syndromes require knowledge of the underlying atherosclerotic plaque pathobiology. Hybrid imaging modalities capable of comprehensive assessment of biochemical and morphological plaques features can address this need. Here we report the first implementation of an intravascular catheter system combining fluorescence lifetime imaging (FLIm) with polarization-sensitive optical coherence tomography (PSOCT). This system provides multi-scale assessment of plaque structure and composition via high spatial resolution morphology from OCT, polarimetry-derived tissue microstructure, and biochemical composition from FLIm, without requiring any molecular contrast agent. This result was achieved with a low profile (2.7 Fr) double-clad fiber (DCF) catheter and high speed (100 fps B-scan rate, 40 mm/s pullback speed) console. Use of a DCF and broadband rotary junction required extensive optimization to mitigate the reduction in OCT performance originating from additional reflections and multipath artifacts. This challenge was addressed by the development of a broad-band (UV-visible-IR), high return loss (47 dB) rotary junction. We demonstrate in phantoms,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.