Evidence map›Paper›PMID 38633044›Full record

ArticleNanoscale advances2024

Doxorubicin loaded thermostable nanoarchaeosomes: a next-generation drug carrier for breast cancer therapeutics.

Kaviya Vijayalakshmi Babunagappan, Abirami Seetharaman, Subastri Ariraman, Poornima Budime Santhosh, Julia Genova, Natasa Poklar Ulrih, Swathi Sudhakar

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Kaviya Vijayalakshmi BabunagappanDepartment of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras Chennai India swathi.s@iitm.ac.in.
Abirami SeetharamanDepartment of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras Chennai India swathi.s@iitm.ac.in.
Subastri AriramanDepartment of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras Chennai India swathi.s@iitm.ac.in.
Poornima Budime SanthoshInstitute of Solid State Physics, Bulgarian Academy of Sciences Tzarigradsko Chausee Sofia Bulgaria.
Julia GenovaInstitute of Solid State Physics, Bulgarian Academy of Sciences Tzarigradsko Chausee Sofia Bulgaria.
Natasa Poklar UlrihDepartment of Food Science and Technology, Biotechnical Faculty, University of Ljubljana Ljubljana Slovenia.ORCID https://orcid.org/0000-0002-2731-9973
Swathi SudhakarDepartment of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras Chennai India swathi.s@iitm.ac.in.
Indian Institute of Technology Madras · INGeorgi Nadjakov Institute of Solid State Physics · BGUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer has a poor prognosis due to the toxic side effects associated with high doses of chemotherapy. Liposomal drug encapsulation has resulted in clinical success in enhancing chemotherapy tolerability. However, the formulation faces severe limitations with a lack of colloidal stability, reduced drug efficiency, and difficulties in storage conditions. Nanoarchaeosomes (NA) are a new generation of highly stable nanovesicles composed of the natural ether lipids extracted from archaea. In our study, we synthesized and characterized the NA, evaluated their colloidal stability, drug release potential, and anticancer efficacy. Transmission electron microscopy images have shown that the NA prepared from the hyperthermophilic archaeon

Identifiers

PMID38633044
PMCPMC11019490
OpenAlexW4390512038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.