Evidence map›Paper›PMID 38632934›Full record

Observational studyEuropean journal of ophthalmology2024

The HUC progression score: A new method for determining KERATOCONUS progression.

Beatriz de Luis Eguileor, Borja Santos Zorrozúa, Jaime Etxebarria Ecenarro

Abstract readObservational Study
In one paragraph

Observational study in European journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Keratoconus progression assessment].Die Ophthalmologie · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Beatriz de Luis EguileorDeparment of Ophthalmology, BioCruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.ORCID 0000-0003-4215-8722
Borja Santos ZorrozúaScientific Coordination Unit, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, Bilbao, Basque Country, Spain.
Jaime Etxebarria EcenarroDeparment of Ophthalmology, BioCruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.ORCID 0000-0002-7650-9132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo establish new criteria for the progression of keratoconus, taking into account a Pentacam HR (high resolution) tomographeŕs repeatability limit.

methodsThis is a retrospective observational study, including 224 eyes in 154 patients diagnosed with keratoconus and patients treated with crosslinking, with a follow-up of at least one year, in which the new progression score of the Cruces University Hospital for keratoconus progression was analyzed. This score takes into account: maximum keratometry, thinnest corneal thickness, maximum posterior elevation, vertical coma and RMS of high order aberrations, all based on the tomographer repeatability limit. The effectiveness or not of crosslinking was determined.

resultsThe Receiver Operating Characteristics (ROC) curves obtained in our validation met the criteria by being far from the reference diagonal. Moreover, young patients are more likely to have keratoconus that progresses, and the percentage of patients that showed progression was 14.3% of the eyes studied, with the most advanced keratoconus showing the least progression. Taking into account the new progression score of the Cruces Hospital, we would have indicated crosslinking in 2 eyes only and we observed that none progressed one year after treatment.

conclusionsThe the new progression score of the Cruces University Hospital is a method based on the real repeatability limit for keratoconic eyes. Moreover, it is easy to interpret and can be implemented with Pentacam software. It provides a numerical value that evaluates both the anterior and posterior surfaces of the cornea and corneal aberrations in the evolution of keratoconus.

Indexed as

CorneaCorneal TopographyDisease ProgressionKeratoconusROC CurveAdolescentAdultCollagenCross-Linking ReagentsFemaleFollow-Up StudiesHumansMaleMiddle AgedPhotochemotherapyPhotosensitizing AgentsCollagenCross-Linking ReagentsPhotosensitizing AgentsRiboflavinCORNEA / EXTERNAL DISEASEcorneal degenerations < CORNEA / EXTERNAL DISEASEexamination techniques < CORNEA / EXTERNAL DISEASEexamination techniques: corneal topography/Keratometry < CORNEA / EXTERNAL DISEASEexamination techniques: pachimetry < CORNEA / EXTERNAL DISEASE

Identifiers

PMID38632934
PMCPMC11295412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.